التفاصيل البيبلوغرافية
| العنوان: |
Association of estimated glucose disposal rate with metabolic syndrome prevalence and mortality risks: a population-based study |
| المؤلفون: |
Xiaoli Chen, Aihua Li, Qilin Ma |
| المصدر: |
Cardiovascular Diabetology, Vol 24, Iss 1, Pp 1-12 (2025) |
| بيانات النشر: |
BMC, 2025. |
| سنة النشر: |
2025 |
| المجموعة: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: |
Insulin resistance, Metabolic syndrome, Estimated glucose disposal rate, NHANES, Mortality, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: |
Abstract Background Insulin resistance (IR) is a central pathophysiological factor in metabolic syndrome (MetS) and an essential driver of cardiovascular disease (CVD) and mortality. The estimated glucose disposal rate (eGDR) is a reliable marker of IR and has been associated with CVD prognosis. This study aims to examine the relationship between eGDR, MetS, and their predictive roles in clinical outcomes. Methods Data from the NHANES (2001–2018) were utilized, with a cross-sectional design applied to evaluate the association between eGDR and MetS prevalence, and a cohort design employed for mortality follow-up. Weighted logistic regression models were used to examine the association between eGDR and MetS. Weighted Cox proportional hazard models were applied to assess the link between eGDR and both all-cause and CVD mortality. To examine the non-linear associations between the eGDR, MetS, and mortality outcomes, restricted cubic spline (RCS) analysis was applied. Additionally, the predictive performance of eGDR, and other IR indices (TyG, HOMA-IR), for mortality was assessed using the C-statistic. Results A robust negative association between eGDR and MetS prevalence was found, following full covariate adjustment (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1475-2840 |
| Relation: |
https://doaj.org/toc/1475-2840 |
| DOI: |
10.1186/s12933-025-02599-7 |
| URL الوصول: |
https://doaj.org/article/2cb42e94e217402d9a69fc22b38cdff2 |
| رقم الانضمام: |
edsdoj.2cb42e94e217402d9a69fc22b38cdff2 |
| قاعدة البيانات: |
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