التفاصيل البيبلوغرافية
| العنوان: |
Advantages of a multi-state approach in surgical research: how intermediate events and risk factor profile affect the prognosis of a patient with locally advanced rectal cancer |
| المؤلفون: |
G. Manzini, T. J. Ettrich, M. Kremer, M. Kornmann, D. Henne-Bruns, D. A. Eikema, P. Schlattmann, L. C. de Wreede |
| المصدر: |
BMC Medical Research Methodology, Vol 18, Iss 1, Pp 1-11 (2018) |
| بيانات النشر: |
BMC, 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Medicine (General) |
| مصطلحات موضوعية: |
Multi-state model (msm), Dynamic prediction, Rectal cancer (RC), Local recurrence (LR), Distant metastasis (DM), Medicine (General), R5-920 |
| الوصف: |
Abstract Background Standard survival analysis fails to give insight into what happens to a patient after a first outcome event (like first relapse of a disease). Multi-state models are a useful tool for analyzing survival data when different treatments and results (intermediate events) can occur. Aim of this study was to implement a multi-state model on data of patients with rectal cancer to illustrate the advantages of multi-state analysis in comparison to standard survival analysis. Methods We re-analyzed data from the RCT FOGT-2 study by using a multi-state model. Based on the results we defined a high and low risk reference patient. Using dynamic prediction, we estimated how the survival probability changes as more information about the clinical history of the patient becomes available. Results A patient with stage UICC IIIc (vs UICC II) has a higher risk to develop distant metastasis (DM) or both DM and local recurrence (LR) if he/she discontinues chemotherapy within 6 months or between 6 and 12 months, as well as after the completion of 12 months CTx with HR 3.55 (p = 0.026), 5.33 (p = 0.001) and 3.37 (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-2288 |
| Relation: |
http://link.springer.com/article/10.1186/s12874-018-0476-z; https://doaj.org/toc/1471-2288 |
| DOI: |
10.1186/s12874-018-0476-z |
| URL الوصول: |
https://doaj.org/article/2c6c550c8b4f461f93290604ecdc2499 |
| رقم الانضمام: |
edsdoj.2c6c550c8b4f461f93290604ecdc2499 |
| قاعدة البيانات: |
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