التفاصيل البيبلوغرافية
| العنوان: |
Fertility regulatory potential of Persicaria hydropiper (L.) Delarbre methanolic root extract in female albino mice: An insight into the phytochemicals present and role of the extract in contraception |
| المؤلفون: |
Juli Bairagi, Purba J Saikia, Freeman Boro, Ajit Hazarika |
| المصدر: |
Saudi Pharmaceutical Journal, Vol 30, Iss 11, Pp 1623-1638 (2022) |
| بيانات النشر: |
Elsevier, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: |
Antifertility potential, GCMS, Estrous cycle, Uterine histology, Persicaria hydropiper, Total cholesterol, Therapeutics. Pharmacology, RM1-950 |
| الوصف: |
People from some parts of the world traditionally depend on different herbal medicines for fertility regulation. The Mishing women of Assam, India have been using the dry root powder of Persicaria hydropiper for years as a birth control medicine. The present study was designed to investigate the chemical composition of methanolic extract from the dry roots of P. hydropiper as well as to study its anti-implantation effect. P. hydropiper roots were collected from paddy fields and the methanolic extract was prepared using dry powdered roots. Gas chromatography-mass spectrometry (GCMS) analysis of the methanolic root extract was performed for phytochemical analysis. The estrous cycle of the female mice was monitored by observation of the cells in the vaginal smear. The estrogenic and anti-implantation effect was observed using routine histological procedures with Haematoxylin & Eosin staining performed in mice. Total serum cholesterol level was also measured. The GCMS analysis revealed the presence of stigmasterol and 3-deoxyestradiol, which are known to possess antifertility properties. The extract (1000 mg/kg bodyweight dose) altered the duration and sequence of the estrous cycle of cyclic females with a prolonged metestrous of 2 days, followed by an early estrous. There was hyperplasia in the endometrial epithelium and even shedding of the same on high duration treatment on day 6. There was a significant (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1319-0164 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1319016422002274; https://doaj.org/toc/1319-0164 |
| DOI: |
10.1016/j.jsps.2022.09.005 |
| URL الوصول: |
https://doaj.org/article/2c2216ac5aaa433e96330d6f9f73c8c4 |
| رقم الانضمام: |
edsdoj.2c2216ac5aaa433e96330d6f9f73c8c4 |
| قاعدة البيانات: |
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