Academic Journal
Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs
| العنوان: | Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs |
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| المؤلفون: | Ahmed Ludvigsen Al-Mashhadi, Christian Bo Poulsen, Karin von Wachenfeldt, Anna-Karin Robertson, Jacob Fog Bentzon, Lars Bo Nielsen, Jesper Thygesen, Lars Poulsen Tolbod, Jens Rolighed Larsen, Søren Kragh Moestrup, Björn Frendéus, Brynjulf Mortensen, Ludovic Drouet, Rozh H. Al-Mashhadi, Erling Falk |
| المصدر: | Journal of Diabetes Research, Vol 2018 (2018) |
| بيانات النشر: | Hindawi Limited, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Background. Obesity and metabolic syndrome (MetS) are major risk factors for atherosclerotic diseases; however, a causal link remains elusive. Animal models resembling human MetS and its complications, while important, are scarce. We aimed at developing a porcine model of human MetS. Methods. Forty pigs with familial hypercholesterolemia were fed a high fat + fructose diet for 30 weeks. Metabolic assessments and subcutaneous fat biopsies were obtained at 18 and 30 weeks, and fat distribution was assessed by CT-scans. Postmortem, macrophage density, and phenotype in fat tissues were quantified along with atherosclerotic burden. Results. During the experiment, we observed a >4-fold in body weight, a significant but small increase in fasting glucose (4.1 mmol/L), insulin (3.1 mU/L), triglycerides (0.5 mmol/L), and HDL cholesterol (2.6 mmol/L). Subcutaneous fat correlated with insulin resistance, but intra-abdominal fat correlated inversely with insulin resistance and LDL cholesterol. More inflammatory macrophages were found in visceral versus subcutaneous fat, and inflammation decreased in subcutaneous fat over time. Conclusions. MetS based on human criteria was not achieved. Surprisingly, visceral fat seemed part of a healthier metabolic and inflammatory profile. These results differ from human findings, and further research is needed to understand the relationship between obesity and MetS in porcine models. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2314-6745 2314-6753 |
| Relation: | https://doaj.org/toc/2314-6745; https://doaj.org/toc/2314-6753 |
| DOI: | 10.1155/2018/6823193 |
| URL الوصول: | https://doaj.org/article/2c21b3e715324ff9bbb4daf88ef55399 |
| رقم الانضمام: | edsdoj.2c21b3e715324ff9bbb4daf88ef55399 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23146745 23146753 |
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| DOI: | 10.1155/2018/6823193 |