التفاصيل البيبلوغرافية
| العنوان: |
Genomic and functional portrait of multidrug-resistant, hydrogen sulfide (H2S)-producing variants of Escherichia coli |
| المؤلفون: |
Razib Mazumder, Arif Hussain, Mohammad Mustafizur Rahman, Jody E. Phelan, Susana Campino, Ahmed Abdullah, Taane G. Clark, Dinesh Mondal |
| المصدر: |
Frontiers in Microbiology, Vol 14 (2023) |
| بيانات النشر: |
Frontiers Media S.A., 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Microbiology |
| مصطلحات موضوعية: |
atypical H2S-producing E. coli variants, genomics, epidemiology, functional characterization, differential diagnosis, E. coli identification algorithm, Microbiology, QR1-502 |
| الوصف: |
Atypical Escherichia coli forms exhibit unusual characteristics compared to typical strains. The H2S-producing variants of some atypical E. coli strains cause a wide range of illnesses in humans and animals. However, there are sparse reports on such strains worldwide. We performed whole-genome sequencing (WGS) and detailed characterization of four H2S-producing E. coli variants from poultry and human clinical sources in Dhaka, Bangladesh. All four isolates were confirmed as E. coli using biochemical tests and genomic analysis, and were multidrug-resistant (MDR). WGS analysis including an additional Chinese strain, revealed diverse STs among the five H2S-producing E. coli genomes, with clonal complex ST10 being detected in 2 out of 5 genomes. The predominant phylogroup detected was group A (n = 4/5). The blaTEM1B (n = 5/5) was the most predominant extended-spectrum beta-lactamase (ESBL) gene, followed by different alleles of blaCTX-M (blaCTX-M -55,-65,-123; n = 3/5). Multiple plasmid replicons were detected, with IncX being the most common. One E. coli strain was classified as enteropathogenic E. coli. The genomes of all five isolates harbored five primary and four secondary function genes related to H2S production. These findings suggest the potential of these isolates to cause disease and spread antibiotic resistance. Therefore, such atypical E. coli forms should be included in differential diagnosis to understand the pathogenicity, antimicrobial resistance and evolution of H2S-producing E. coli. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-302X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmicb.2023.1206757/full; https://doaj.org/toc/1664-302X |
| DOI: |
10.3389/fmicb.2023.1206757 |
| URL الوصول: |
https://doaj.org/article/e2bdb4b38a4c4df8ba5d4ee5069d99fa |
| رقم الانضمام: |
edsdoj.2bdb4b38a4c4df8ba5d4ee5069d99fa |
| قاعدة البيانات: |
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