Academic Journal
Accumulation of Paneth Cells in Early Colorectal Adenomas Is Associated with Beta-Catenin Signaling and Poor Patient Prognosis
| العنوان: | Accumulation of Paneth Cells in Early Colorectal Adenomas Is Associated with Beta-Catenin Signaling and Poor Patient Prognosis |
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| المؤلفون: | Erika López-Arribillaga, Bing Yan, Teresa Lobo-Jarne, Yolanda Guillén, Silvia Menéndez, Montserrat Andreu, Anna Bigas, Mar Iglesias, Lluís Espinosa |
| المصدر: | Cells, Vol 10, Iss 11, p 2928 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | colorectal cancer, adenomas, stem cell niche, Paneth cells, Wnt, Notch, Cytology, QH573-671 |
| الوصف: | Background: Previous studies in mice indicated that Paneth cells and c-Kit-positive goblet cells represent the stem cell niche of the small intestine and colon, respectively, partly by supporting Wnt and Notch activation. Whether these cell populations play a similar role in human intestinal cancer remains unexplored. Methods: We performed histopathological evaluation and immunohistochemical analysis of early colorectal adenomas and carcinoma adenoma from patients at the Hospital del Mar in Barcelona. We then determined the possible correlation between the different parameters analyzed and with patient outcomes. Results: Paneth cells accumulate in a subset of human colorectal adenomas directly associated with Notch and Wnt/β-catenin activation. Adenoma areas containing Paneth cells display increased vessel density in the lamina propria and higher levels of the stem cell marker EphB2. In an in-house cohort of 200 colorectal adenoma samples, we also observed a significant correlation between the presence of Paneth cells and Wnt activation. Kaplan–Meier analysis indicated that early adenoma patients carrying Paneth cell-positive tumors display reduced disease-free survival compared with patients with Paneth cell-free lesions. Conclusions: Our results indicate that Paneth cells contribute to the initial steps of cancer progression by providing the stem cell niche to adenoma cells, which could be therapeutically exploited. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 10112928 2073-4409 |
| Relation: | https://www.mdpi.com/2073-4409/10/11/2928; https://doaj.org/toc/2073-4409 |
| DOI: | 10.3390/cells10112928 |
| URL الوصول: | https://doaj.org/article/a2b2abc47bf94a33859ea7afe20bbba6 |
| رقم الانضمام: | edsdoj.2b2abc47bf94a33859ea7afe20bbba6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10112928 20734409 |
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| DOI: | 10.3390/cells10112928 |