Academic Journal
Grewiifopenes A–K, bioactive clerodane diterpenoids from Casearia grewiifolia Vent.
| العنوان: | Grewiifopenes A–K, bioactive clerodane diterpenoids from Casearia grewiifolia Vent. |
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| المؤلفون: | Phanruethai Pailee, Paratchata Batsomboon, Wiriya Yaosanit, Theerawat Thananthaisong, Chulabhorn Mahidol, Poonsakdi Ploypradith, Nanthawan Reuk-ngam, Panita Khlaychan, Supanna Techasakul, Somsak Ruchirawat, Vilailak Prachyawarakorn |
| المصدر: | Natural Products and Bioprospecting, Vol 14, Iss 1, Pp 1-19 (2024) |
| بيانات النشر: | SpringerOpen, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Botany |
| مصطلحات موضوعية: | Casearia grewiifolia Vent., Salicaceae, Clerodane diterpenoids, Cytotoxic activity, Antibacterial activity, Botany, QK1-989 |
| الوصف: | Abstract Eleven novel clerodane-type diterpenoids, grewiifopenes A–K (1–4 and 12–18), along with nine known compounds (5–11, 19, and 20) were purified from the dichloromethane extract of the twigs and stems of Casearia grewiifolia Vent. (Salicaceae). Their spectroscopic data, including the NMR, HRESIMS, and electronic circular dichroism calculations were employed to completely characterize and elucidate the chemical structures and absolute configurations. The clerodane diterpenoids possessing a 6-OH group and no substitution at C-7 exhibited greater cytotoxic activity than others, with their IC50 values ranging from 0.3 to 2.9 μM. Isocaseamembrin E (7) exhibited antibacterial activity against Staphylococcus aureus, while isocaseamembrin E (7), corymbulosin X (8), caseargrewiin A (9), kurzipene A (10), and balanspene F (11) exhibited antibacterial activity against Bacillus cereus. Graphical Abstract |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2192-2195 2192-2209 |
| Relation: | https://doaj.org/toc/2192-2195; https://doaj.org/toc/2192-2209 |
| DOI: | 10.1007/s13659-024-00475-7 |
| URL الوصول: | https://doaj.org/article/2ae8a19d535140cdab04757faba9a596 |
| رقم الانضمام: | edsdoj.2ae8a19d535140cdab04757faba9a596 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21922195 21922209 |
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| DOI: | 10.1007/s13659-024-00475-7 |