التفاصيل البيبلوغرافية
| العنوان: |
Seroprevalence of SARS-CoV-2 Infection Among People Living with HIV in Libreville, Gabon |
| المؤلفون: |
Samira Zoa-Assoumou, Hervé M’boyis-Kandem, Pelagie Saphou-Damon, Davy Ulrich Leger Mouangala, Guy-Francis Nzengui, Marina Mbani-Okoumba, Claudine Kombila-Koumavor, Gael Mourembou, Brama Ibrahim, Angelique Ndjoyi-Mbiguino |
| المصدر: |
COVID, Vol 5, Iss 1, p 3 (2024) |
| بيانات النشر: |
MDPI AG, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Specialties of internal medicine |
| مصطلحات موضوعية: |
seroprevalence, SARS-CoV-2 antibodies, PLHIV, Libreville, Specialties of internal medicine, RC581-951 |
| الوصف: |
(1) Objectives: The burden of SARS-CoV-2 infection in people living with HIV (PLHIV) in Gabon is unknown. (2) Methods: We conducted a cross-sectional seroprevalence study of SARS-CoV-2 immunoglobulin (Ig) G/M antibodies in PLHIV in Libreville from April 2022 to April 2023 after the fourth wave of the pandemic. We used the WANTAI SARS-CoV-2 Ab ELISA targeting the SARS-CoV-2 spike, receptor-binding domain. (3) Results: Among 480 samples tested, the seroprevalence of IgG antibodies to SARS-CoV-2 spike protein was 87.5% (95% confidence interval (CI) 77.7–97.3%). History of SARS-CoV-2 diagnosis, ART treatment, and TCD4 lymphocyte count were not found to be associated with the presence of antibodies against SARS-CoV-2 among the study participants. However, having a detectable viral load (p = 0.0001), being vaccinated (COVID-19 vaccine, p = 0.04), and a history of COVID-19 (p < 0.0001) symptoms were associated with a higher risk of having anti-SARS-CoV-2 antibodies. (4) Conclusions: By early 2023, PLHIV in Gabon had high rates of SARS-CoV-2 seropositivity. To our knowledge, this is the first study to determine the seroprevalence of SARS-CoV-2 antibodies in PLHIV in Gabon. This study provides further evidence of anti-SARS-CoV-2 seroconversion in the absence of any vaccination in a particular target population. The surveillance of diseases of global health concern in PLHIV is crucial to estimate population-level exposure and inform public health responses. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2673-8112 |
| Relation: |
https://www.mdpi.com/2673-8112/5/1/3; https://doaj.org/toc/2673-8112 |
| DOI: |
10.3390/covid5010003 |
| URL الوصول: |
https://doaj.org/article/2ae39b7fe63b405d86b698e483dbcb11 |
| رقم الانضمام: |
edsdoj.2ae39b7fe63b405d86b698e483dbcb11 |
| قاعدة البيانات: |
Directory of Open Access Journals |