التفاصيل البيبلوغرافية
| العنوان: |
Comparative Characterization of Human Antibody Response Induced by BNT162b2 Vaccination vs. SARS-CoV-2 Wild-Type Infection |
| المؤلفون: |
Theano Lagousi, John Routsias, Maria Mavrouli, Ioanna Papadatou, Maria Geropeppa, Vana Spoulou |
| المصدر: |
Vaccines, Vol 10, Iss 8, p 1210 (2022) |
| بيانات النشر: |
MDPI AG, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Medicine |
| مصطلحات موضوعية: |
SARS-CoV-2, COVID-19, BNT162b2, humoral immune response, antibodies, Medicine |
| الوصف: |
Humoral immunity after SARS-CoV-2 immunization or natural infection is thought to be evanescent. In our study, we aimed to longitudinally characterize the kinetics of antibody titers after dual BNT162b2 immunization or wild-type infection. Vaccinated and recovered individuals displayed distinct antibody kinetics, as convalescents had detectable RBD-, S1-specific, and neutralizing IgG antibody titers two weeks post-infection that gradually increased longitudinally, while RBD-, S1-specific, and neutralizing IgG were detected in vaccinees after the first dose, increased significantly 3 weeks post the second dose and decreased significantly 4–5 months thereafter. Neutralizing IgG was significantly higher initially in convalescent individuals; however, vaccines displayed significantly higher neutralizing antibodies 4–5 months post the second dose. In both groups, there was a strong negative association between elapsed time and antibody levels. The avidity of anti-RBD antibody titers increased significantly in patients longitudinally, while in vaccinees initially increased, with subsequent decrease, remaining however higher than antibody avidity of recovered individuals at all time-points. Anti-RBD antibodies were strongly correlated with neutralizing and anti-S1 antibodies in both groups at all time-points. This study facilitates our further understanding of immune response to SARS-CoV-2 and vaccines. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2076-393X |
| Relation: |
https://www.mdpi.com/2076-393X/10/8/1210; https://doaj.org/toc/2076-393X |
| DOI: |
10.3390/vaccines10081210 |
| URL الوصول: |
https://doaj.org/article/2a9ee8a919f84b6d83b824a0c637a5f7 |
| رقم الانضمام: |
edsdoj.2a9ee8a919f84b6d83b824a0c637a5f7 |
| قاعدة البيانات: |
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