التفاصيل البيبلوغرافية
| العنوان: |
A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine |
| المؤلفون: |
Longtai You, Chunjing Yang, Yuanyuan Du, Wenping Wang, Mingyi Sun, Jing Liu, Baorui Ma, Linnuo Pang, Yawen Zeng, Zhiqin Zhang, Xiaoxv Dong, Xingbin Yin, Jian Ni |
| المصدر: |
Frontiers in Pharmacology, Vol 11 (2020) |
| بيانات النشر: |
Frontiers Media S.A., 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: |
matrine, pharmacology, toxicology, pharmacokinetics, mechanisms, Therapeutics. Pharmacology, RM1-950 |
| الوصف: |
Matrine (MT) is a naturally occurring alkaloid and an bioactive component of Chinese herbs, such as Sophora flavescens and Radix Sophorae tonkinensis. Emerging evidence suggests that MT possesses anti-cancer, anti-inflammatory, anti-oxidant, antiviral, antimicrobial, anti-fibrotic, anti-allergic, antinociceptive, hepatoprotective, cardioprotective, and neuroprotective properties. These pharmacological properties form the foundation for its application in the treatment of various diseases, such as multiple types of cancers, hepatitis, skin diseases, allergic asthma, diabetic cardiomyopathy, pain, Alzheimer’s disease (AD), Parkinson’s disease (PD), and central nervous system (CNS) inflammation. However, an increasing number of published studies indicate that MT has serious adverse effects, the most obvious being liver toxicity and neurotoxicity, which are major factors limiting its clinical use. Pharmacokinetic studies have shown that MT has low oral bioavailability and short half-life in vivo. This review summarizes the latest advances in research on the pharmacology, toxicology, and pharmacokinetics of MT, with a focus on its biological properties and mechanism of action. The review provides insight into the future of research on traditional Chinese medicine. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1663-9812 |
| Relation: |
https://www.frontiersin.org/article/10.3389/fphar.2020.01067/full; https://doaj.org/toc/1663-9812 |
| DOI: |
10.3389/fphar.2020.01067 |
| URL الوصول: |
https://doaj.org/article/2a35186e4d46435d98012afed1dccf01 |
| رقم الانضمام: |
edsdoj.2a35186e4d46435d98012afed1dccf01 |
| قاعدة البيانات: |
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