Academic Journal
Co-administration of sodium hydrosulfide and tadalafil modulates hypoxia and oxidative stress on bladder dysfunction in a rat model of bladder outlet obstruction
| العنوان: | Co-administration of sodium hydrosulfide and tadalafil modulates hypoxia and oxidative stress on bladder dysfunction in a rat model of bladder outlet obstruction |
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| المؤلفون: | Didem Yilmaz-Oral, Ecem Kaya-Sezginer, Heba Asker, Serap Gur |
| المصدر: | International Brazilian Journal of Urology, Vol 48, Iss 6, Pp 971-980 (2022) |
| بيانات النشر: | Sociedade Brasileira de Urologia, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | Prostatic Hyperplasia, Urinary Bladder, Overactive, Hydrogen Sulfide, Tadalafil, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | ABSTRACT Purpose: This study aimed to assess the possible healing effect of combination treatment with a hydrogen sulfide (H2S) donor, sodium hydrosulfide (NaHS) plus tadalafil on partial bladder outlet obstruction (PBOO)-induced bladder dysfunction. Materials and Methods: A total of 75 male Sprague-Dawley rats aged 10-wk and 300-350g were divided into five groups; control; PBOO; PBOO+NaHS (5.6mg/kg/day, i.p., 6-wk); PBOO+tadalafil (2mg/kg/day, oral, 6-wk) and PBOO+NaHS+tadalafil. PBOO was created by partial urethral ligation. 6 weeks after obstruction, the in vitro contractile responses of the detrusor muscle and Western blotting, H2S and malondialdehyde assay were performed in bladder tissues. Results: There was an increase in bladder weight(p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1677-6119 1677-5538 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382022000600971&tlng=en; https://doaj.org/toc/1677-6119 |
| DOI: | 10.1590/s1677-5538.ibju.2022.0207 |
| URL الوصول: | https://doaj.org/article/2a315b9134554ea1ad0eb0e9ac5266ca |
| رقم الانضمام: | edsdoj.2a315b9134554ea1ad0eb0e9ac5266ca |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16776119 16775538 |
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| DOI: | 10.1590/s1677-5538.ibju.2022.0207 |