التفاصيل البيبلوغرافية
| العنوان: |
Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model |
| المؤلفون: |
Arata Oh-Nishi, Yuji Nagai, Chie Seki, Tetsuya Suhara, Takafumi Minamimoto, Makoto Higuchi |
| المصدر: |
Brain, Behavior, & Immunity - Health, Vol 22, Iss , Pp 100446- (2022) |
| بيانات النشر: |
Elsevier, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
Maternal immune activation, Schizophrenia, Dopamine D2 receptors, Dopamine, Anterior cingulate cortex, Poly I:C, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
Maternal immune activation (MIA) is a risk factor for schizophrenia in the offspring. MIA in pregnant rodents can be induced by injection of synthetic polyriboinosinic-polyribocytidilic acid (Poly I:C), which causes decreased striatal dopamine D2 receptor (D2R) expression and behavioral dysfunction mediated by the dopaminergic system in the offspring. However, previous studies did not determine whether Poly I:C induced cortical dopamine D2R abnormality in an MIA rat model. In this study, we performed micro-positron emission tomography (micro-PET) in vivo imaging and ex vivo neurochemical analyses of cortical D2Rs in MIA. In the micro-PET analyses, the anterior cingulate cortex (ACC) region in the offspring showed significantly reduced binding potential for [11C]FLB457, a high affinity radio-ligand toward D2Rs. Neurochemical analysis showed reduction of D2Rs and augmentation of dopamine turnover in the ACC of the rat offspring. Thus, MIA induces dopaminergic dysfunction in the ACC of offspring, similar to the neuronal pathology reported in patients with schizophrenia. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2666-3546 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2666354622000369; https://doaj.org/toc/2666-3546 |
| DOI: |
10.1016/j.bbih.2022.100446 |
| URL الوصول: |
https://doaj.org/article/296e3bf993cc4e2fa09a2c9bd1817497 |
| رقم الانضمام: |
edsdoj.296e3bf993cc4e2fa09a2c9bd1817497 |
| قاعدة البيانات: |
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