Academic Journal
Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults
| العنوان: | Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults |
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| المؤلفون: | Isabel J. Sible, Belinda Yew, Jung Yun Jang, John Paul M. Alitin, Yanrong Li, Aimée Gaubert, Amy Nguyen, Shubir Dutt, Anna E. Blanken, Jean K. Ho, Anisa J. Marshall, Arunima Kapoor, Fatemah Shenasa, Kathleen E. Rodgers, Virginia E. Sturm, Elizabeth Head, Alessandra Martini, Daniel A. Nation |
| المصدر: | Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022) |
| بيانات النشر: | Nature Portfolio, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Blood pressure variability is an emerging risk factor for Alzheimer’s disease in older adults, independent of average blood pressure levels. Growing evidence suggests increased blood pressure variability is linked to Alzheimer’s disease pathophysiology indexed by cerebrospinal fluid and positron emission tomography markers, but relationships with plasma Alzheimer’s disease markers have not been investigated. In this cross-sectional study of 54 community-dwelling older adults (aged 55–88, mean age 69.9 [8.2 SD]), elevated blood pressure variability over 5 min was associated with lower levels of plasma Aβ1–42 (standardized ß = − 0.36 [95% CI − 0.61, − 0.12]; p = 0.005; adjusted R 2 = 0.28) and Aβ1–42: Aβ1–40 ratio (ß = − 0.49 [95% CI − 0.71, − 0.22]; p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-022-20627-4 |
| URL الوصول: | https://doaj.org/article/c28d0b1f470344b8a46d539c7dfa9fc2 |
| رقم الانضمام: | edsdoj.28d0b1f470344b8a46d539c7dfa9fc2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-022-20627-4 |