The evolutionary safety of mutagenic drugs should be assessed before drug approval.

التفاصيل البيبلوغرافية
العنوان:	The evolutionary safety of mutagenic drugs should be assessed before drug approval.
المؤلفون:	Gabriela Lobinska, Vyacheslav Tretyachenko, Orna Dahan, Martin A Nowak, Yitzhak Pilpel
المصدر:	PLoS Biology, Vol 22, Iss 3, p e3002570 (2024)
بيانات النشر:	Public Library of Science (PLoS), 2024.
سنة النشر:	2024
المجموعة:	LCC:Biology (General)
مصطلحات موضوعية:	Biology (General), QH301-705.5
الوصف:	Some drugs increase the mutation rate of their target pathogen, a potentially concerning mechanism as the pathogen might evolve faster toward an undesired phenotype. We suggest a four-step assessment of evolutionary safety for the approval of such treatments.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	1544-9173 1545-7885 32851855
Relation:	https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002570&type=printable; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885
DOI:	10.1371/journal.pbio.3002570&type=printable
DOI:	10.1371/journal.pbio.3002570
URL الوصول:	https://doaj.org/article/2890d1a322b94caeb3285185535317c4
رقم الانضمام:	edsdoj.2890d1a322b94caeb3285185535317c4
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	15449173 15457885 32851855
DOI:	10.1371/journal.pbio.3002570&type=printable