Academic Journal
Elevated medial temporal lobe and pervasive brain tau‐PET signal in normal participants
| العنوان: | Elevated medial temporal lobe and pervasive brain tau‐PET signal in normal participants |
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| المؤلفون: | Val J. Lowe, Tyler J. Bruinsma, Hoon‐Ki Min, Emily S. Lundt, Ping Fang, Matthew L. Senjem, Bradley F. Boeve, Keith A. Josephs, Mukesh K. Pandey, Melissa E. Murray, Kejal Kantarci, David T. Jones, Christopher G. Schwarz, David S. Knopman, Ronald C. Petersen, Clifford R. Jack Jr. |
| المصدر: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 210-216 (2018) |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system LCC:Geriatrics |
| مصطلحات موضوعية: | Tau‐PET, Alzheimer's disease, AV‐1451, Imaging, Cognitively normal, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6 |
| الوصف: | Abstract Introduction Medial temporal lobe (MTL) uptake on tau–positron emission tomography (PET) is seen not only in Alzheimer's disease (AD) dementia but also in the aging population. The relationship of these findings to the development of AD dementia needs to be better understood. Methods Tau‐PET with AV‐1451 was performed on 576 cognitively unimpaired (CU) participants aged 50–94 years. The number of CUs with and without abnormal MTL regions and those with or without extra‐MTL abnormalities was determined. Left and right regions were compared within each subject. Results Of CUs, 58% (334/576) had abnormal tau‐PET findings. MTL abnormalities were present in 41% (238/576) of subjects. Discussion MTL tau‐PET signal is often associated with abnormal extra‐MTL tau‐PET signal in CU participants and may represent neurofibrillary tangle development that could identify participants most likely to develop AD dementia. Tau‐PET signal exclusively outside of the MTL is seen in 17% of CU participants and could be the initial findings in participants in different AD dementia pathways. Significant (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-8729 |
| Relation: | https://doaj.org/toc/2352-8729 |
| DOI: | 10.1016/j.dadm.2018.01.005 |
| URL الوصول: | https://doaj.org/article/27e59870c74d4a9facc689b5ee9ab949 |
| رقم الانضمام: | edsdoj.27e59870c74d4a9facc689b5ee9ab949 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23528729 |
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| DOI: | 10.1016/j.dadm.2018.01.005 |