Academic Journal
Enhancement of asynchronous release from fast-spiking interneuron in human and rat epileptic neocortex.
| العنوان: | Enhancement of asynchronous release from fast-spiking interneuron in human and rat epileptic neocortex. |
|---|---|
| المؤلفون: | Man Jiang, Jie Zhu, Yaping Liu, Mingpo Yang, Cuiping Tian, Shan Jiang, Yonghong Wang, Hui Guo, Kaiyan Wang, Yousheng Shu |
| المصدر: | PLoS Biology, Vol 10, Iss 5, p e1001324 (2012) |
| بيانات النشر: | Public Library of Science (PLoS), 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | Biology (General), QH301-705.5 |
| الوصف: | Down-regulation of GABAergic inhibition may result in the generation of epileptiform activities. Besides spike-triggered synchronous GABA release, changes in asynchronous release (AR) following high-frequency discharges may further regulate epileptiform activities. In brain slices obtained from surgically removed human neocortical tissues of patients with intractable epilepsy and brain tumor, we found that AR occurred at GABAergic output synapses of fast-spiking (FS) neurons and its strength depended on the type of connections, with FS autapses showing the strongest AR. In addition, we found that AR depended on residual Ca²⁺ at presynaptic terminals but was independent of postsynaptic firing. Furthermore, AR at FS autapses was markedly elevated in human epileptic tissue as compared to non-epileptic tissue. In a rat model of epilepsy, we found similar elevation of AR at both FS autapses and synapses onto excitatory neurons. Further experiments and analysis showed that AR elevation in epileptic tissue may result from an increase in action potential amplitude in the FS neurons and elevation of residual Ca²⁺ concentration. Together, these results revealed that GABAergic AR occurred at both human and rat neocortex, and its elevation in epileptic tissue may contribute to the regulation of epileptiform activities. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1544-9173 1545-7885 |
| Relation: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22589699/?tool=EBI; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885 |
| DOI: | 10.1371/journal.pbio.1001324 |
| URL الوصول: | https://doaj.org/article/27e43aacf71547879dfee2470702ea06 |
| رقم الانضمام: | edsdoj.27e43aacf71547879dfee2470702ea06 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15449173 15457885 |
|---|---|
| DOI: | 10.1371/journal.pbio.1001324 |