Academic Journal
Structural and Mechanical Evaluation of Polycaprolactone Scaffold with the Gradient Porous Microstructure for Bone Tissue Engineering
| العنوان: | Structural and Mechanical Evaluation of Polycaprolactone Scaffold with the Gradient Porous Microstructure for Bone Tissue Engineering |
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| المؤلفون: | M. Akbari Taemeh, B. Akbari, J. Nourmohammadi |
| المصدر: | Journal of Advanced Materials in Engineering, Vol 37, Iss 3, Pp 75-86 (2018) |
| بيانات النشر: | Isfahan University of Technology, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Materials of engineering and construction. Mechanics of materials |
| مصطلحات موضوعية: | polycaprolactone (pcl), gradient scaffold, pore size, layer-by-layer assembly, porogen leaching., Materials of engineering and construction. Mechanics of materials, TA401-492 |
| الوصف: | In gradient scaffolds, changes in porosity, pore size or chemical composition occur gradually. Recently, different methods have been applied to create gradient in the scaffolds, but they have some disadvantages such as high cost and control. The main purpose of this research was to fabricate porous gradient scaffolds by a novel, functional, simple, and low-cost method. Two homogenous scaffolds (Homog 1 and Homog 2) and two gradient scaffolds (Grad 1 and Grad 2) were fabricated and compared. Polycaprolactone scaffolds with the pore size gradient along the radial direction were fabricated by combining layer-by-layer assembly and porogen leaching techniques. Paraffin micro particles were used as porogen in two size ranges: 250 to 420 µm and 420 to 600 µm. The average pore size of Homog 1 and Homog 2 was 278.48 ± 11.23 µm and 417.79 ± 14.62, which were suitable for bone tissue engineering. The porosity of the samples was: Homog 1: 77.5 ± 1.25 %, Homog 2: 61.3 ± 3.5 %, Grad 1: 74 ± 0.5 % and Grad 2: 79.8 ± 4 %. It should be stated that the required porosity for cell survival and growth was above 70 %. Compressive strength at 80% strain and compressive modulus for Homog 1, Homog 2, Grad 1 and Grad 2 were 0.16 ± 0.16 MPa and 0.25 ± 0.11 MPa, 0.26 ± 0.20 MPa and 0.53 ± 0.34 MPa, 0.19 ± 0.34 MPa and 0.33 ± 0.43 MPa, 0.12 ± 0.28 MPa and 0.16 ± 0.51 MPa, respectively. The results showed that pore size gradient had a negligible effect on the mechanical properties of the scaffolds and using polycaprolactone (PCL) as the only material of scaffold was not appropriate. The structure of gradient scaffolds showed the radial pore size gradient with a good adhesion between layers without any detectable interface; the result of the compression test also confirmed it. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Persian |
| تدمد: | 2251-600X 2423-5733 |
| Relation: | http://jame.iut.ac.ir/article-1-921-en.html; https://doaj.org/toc/2251-600X; https://doaj.org/toc/2423-5733 |
| URL الوصول: | https://doaj.org/article/aa27d92269ce4efb8fdd5d42b1362e67 |
| رقم الانضمام: | edsdoj.27d92269ce4efb8fdd5d42b1362e67 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 2251600X 24235733 |
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