التفاصيل البيبلوغرافية
| العنوان: |
CardioAtlas: deciphering the single-cell transcriptome landscape in cardiovascular tissues and diseases |
| المؤلفون: |
Tiantongfei Jiang, Xiaoyan Jin, Yueying Gao, Weiwei Zhou, Jinyang Yu, Yongsheng Li, Juan Xu, Benzhi Cai |
| المصدر: |
Biomarker Research, Vol 12, Iss 1, Pp 1-5 (2024) |
| بيانات النشر: |
BMC, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: |
Therapeutics. Pharmacology, RM1-950 |
| الوصف: |
Abstract Increasing scRNA-seq data in cardiovascular research have substantially improved our knowledge on the development of the cardiovascular system and the mechanisms underlying cardiovascular diseases. However, the single-cell transcriptome datasets were dispersed in literature and no resource for cardiovascular systems and diseases. Here, we constructed an organized resource CardioAtlas, which provides comprehensive analysis results for > 1,929,000 cells in 27 human data sets and > 1,088,000 cells in 39 mouse data sets. Through large-scale literature retrieval and manual annotation, we constructed 12 and 15 scRNA-seq reference atlas for common human and mouse cardiovascular systems and diseases, covering 43 and 39 cell types. In particular, CardioAtlas provides five analytic modules, including cell-type prediction, identification of marker genes, functional enrichment analysis, identification of cell-type-specific transcription regulons, and cell-cell communication analysis. In addition, users can upload scRNA-seq data for personalized analysis. CardioAtlas is available at http://bio-bigdata.hrbmu.edu.cn/CardioAtlas . CardioAtlas provides the first comprehensive and well-crafted reference atlas of cardiovascular systems and diseases and describes in detail previously unrecognized cell populations across a large number of humans and mice. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2050-7771 |
| Relation: |
https://doaj.org/toc/2050-7771 |
| DOI: |
10.1186/s40364-024-00696-5 |
| URL الوصول: |
https://doaj.org/article/27c658b0538a4ec59f3b60a54549f5f6 |
| رقم الانضمام: |
edsdoj.27c658b0538a4ec59f3b60a54549f5f6 |
| قاعدة البيانات: |
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