التفاصيل البيبلوغرافية
| العنوان: |
Intravenous arachnoid granulation hypertrophy in patients with Parkinson disease |
| المؤلفون: |
Melanie Leguizamon, Colin D. McKnight, Tristan Ponzo, Jason Elenberger, Jarrod J. Eisma, Alexander K. Song, Paula Trujillo, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen, Kilian Hett |
| المصدر: |
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-10 (2024) |
| بيانات النشر: |
Nature Portfolio, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: |
Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: |
Abstract Intravenous arachnoid granulations (AGs) are protrusions of the arachnoid membrane into the venous lumen and function as contributors to the cerebrospinal fluid (CSF) flow circuit. Patients with Parkinson disease (PD) often present with accumulation of alpha synuclein. Previous works have provided evidence for neurofluid circulation dysfunction in neurodegenerative diseases associated with changes in CSF egress, which may have implications regarding AG morphology. The present study aims to investigate group differences in AG volumetrics between healthy and PD participants, as well as relationships between AG characteristics and clinical assessments. Generalized linear models revealed significant increases in AG volumetrics and number in PD compared to healthy controls. Partial Spearman-rank correlation analyses demonstrated significant relationships between AG metrics and motor and cognitive assessments. Finally, AG volumetrics were positively correlated with objective actigraphy measures of sleep dysfunction, but not self-report sleep symptoms. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2373-8057 |
| Relation: |
https://doaj.org/toc/2373-8057 |
| DOI: |
10.1038/s41531-024-00796-x |
| URL الوصول: |
https://doaj.org/article/27b4d6ccc982454ca3f3069043e82b4a |
| رقم الانضمام: |
edsdoj.27b4d6ccc982454ca3f3069043e82b4a |
| قاعدة البيانات: |
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