التفاصيل البيبلوغرافية
| العنوان: |
PTEN inhibitor bisperoxovanadium protects against noise-induced hearing loss |
| المؤلفون: |
Bei Fan, Fei Lu, Wei-Jia Du, Jun Chen, Xiao-Gang An, Ren-Feng Wang, Wei Li, Yong-Li Song, Ding-Jun Zha, Fu-Quan Chen |
| المصدر: |
Neural Regeneration Research, Vol 18, Iss 7, Pp 1601-1606 (2023) |
| بيانات النشر: |
Wolters Kluwer Medknow Publications, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: |
acoustic trauma, akt, oxidative stress, bisperoxovanadium, cochlear hair cells loss, inner hair cell ribbons loss, noise exposure, permanent threshold shift, phosphatase and tensin homologue deleted on chromosome ten, phosphatidylinositol 3 kinase, sipten, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: |
Studies have shown that phosphatase and tensin homolog deleted on chromosome ten (PTEN) participates in the regulation of cochlear hair cell survival. Bisperoxovanadium protects against neurodegeneration by inhibiting PTEN expression. However, whether bisperoxovanadium can protect against noise-induced hearing loss and the underlying mechanism remains unclear. In this study, we established a mouse model of noise-induced hearing loss by exposure to 105 dB sound for 2 hours. We found that PTEN expression was increased in the organ of Corti, including outer hair cells, inner hair cells, and lateral wall tissues. Intraperitoneal administration of bisperoxovanadium decreased the auditory threshold and the loss of cochlear hair cells and inner hair cell ribbons. In addition, noise exposure decreased p-PI3K and p-Akt levels. Bisperoxovanadium preconditioning or PTEN knockdown upregulated the activity of PI3K-Akt. Bisperoxovanadium also prevented H2O2-induced hair cell death by reducing mitochondrial reactive oxygen species generation in cochlear explants. These findings suggest that bisperoxovanadium reduces noise-induced hearing injury and reduces cochlear hair cell loss. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1673-5374 |
| Relation: |
http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=7;spage=1601;epage=1606;aulast=Fan; https://doaj.org/toc/1673-5374 |
| DOI: |
10.4103/1673-5374.358606 |
| URL الوصول: |
https://doaj.org/article/a271bc82cc2b493bb06a63b94a263500 |
| رقم الانضمام: |
edsdoj.271bc82cc2b493bb06a63b94a263500 |
| قاعدة البيانات: |
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