التفاصيل البيبلوغرافية
| العنوان: |
Indocyanine Green-Camptothecin Co-Loaded Perfluorocarbon Double-Layer Nanocomposite: A Versatile Nanotheranostics for Photochemotherapy and FDOT Diagnosis of Breast Cancer |
| المؤلفون: |
Yu-Hsiang Lee, Po-Wei Kuo, Chun-Ju Chen, Chu-Jih Sue, Ya-Fen Hsu, Min-Chun Pan |
| المصدر: |
Pharmaceutics, Vol 13, Iss 9, p 1499 (2021) |
| بيانات النشر: |
MDPI AG, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: |
breast cancer, indocyanine green, camptothecin, perfluorocarbon, double emulsion, photochemotherapy, Pharmacy and materia medica, RS1-441 |
| الوصف: |
Breast cancer remains the most frequently diagnosed cancer and is the leading cause of neoplastic disease burden for females worldwide, suggesting that effective therapeutic and/or diagnostic strategies are still urgently needed. In this study, a type of indocyanine green (ICG) and camptothecin (CPT) co-loaded perfluorocarbon double-layer nanocomposite named ICPNC was developed for detection and photochemotherapy of breast cancer. The ICPNCs were designed to be surface modifiable for on-demand cell targeting and can serve as contrast agents for fluorescence diffuse optical tomography (FDOT). Upon near infrared (NIR) irradiation, the ICPNCs can generate a significantly increased production of singlet oxygen compared to free ICG, and offer a comparable cytotoxicity with reduced chemo-drug dosage. Based on the results of animal study, we further demonstrated that the ICPNCs ([ICG]/[CPT] = 40-/7.5-μM) in association with 1-min NIR irradiation (808 nm, 6 W/cm2) can provide an exceptional anticancer effect to the MDA-MB-231 tumor-bearing mice whereby the tumor size was significantly reduced by 80% with neither organ damage nor systemic toxicity after a 21-day treatment. Given a number of aforementioned merits, we anticipate that the developed ICPNC is a versatile theranostic nanoagent which is highly promising to be used in the clinic. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1999-4923 |
| Relation: |
https://www.mdpi.com/1999-4923/13/9/1499; https://doaj.org/toc/1999-4923 |
| DOI: |
10.3390/pharmaceutics13091499 |
| URL الوصول: |
https://doaj.org/article/265861e8217f4dd58c9dd9092cac1c1c |
| رقم الانضمام: |
edsdoj.265861e8217f4dd58c9dd9092cac1c1c |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder