Academic Journal
Maternal F-53B exposure during pregnancy and lactation affects bone growth and development in male offspring
| العنوان: | Maternal F-53B exposure during pregnancy and lactation affects bone growth and development in male offspring |
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| المؤلفون: | Lihua Feng, Yuanyuan Lang, Yueying Feng, Xiaomin Tang, Qingqing Zhang, Hengyi Xu, Yang Liu |
| المصدر: | Ecotoxicology and Environmental Safety, Vol 279, Iss , Pp 116501- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Environmental pollution LCC:Environmental sciences |
| مصطلحات موضوعية: | F-53B, Offspring mice, Bone growth, IGF-1/OPG/RANKL/CTSK signaling pathway, Osteoporosis, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350 |
| الوصف: | 6:2 Chlorinated polyfluoroalkyl ether sulfonate (F-53B) is a new type of perfluorinated and polyfluoroalkyl substance (PFAS) that is used extensively in industry and manufacturing. F-53B causes damage to multiple mammalian organs. However, the impacts of F-53B on bone are unknown. Maternal exposure to F-53B is of particular concern because of the vulnerability of the developing fetus and newborn to contaminants from the mother. The goal of this study was to examine the impacts of maternal F-53B exposure on bone growth and development in offspring and to explore its underlying mechanisms. Herein, C57BL/6 J mice were given free access to deionized water containing 0, 0.57, or 5.7 mg/L F-53B during pregnancy and lactation. F-53B exposure resulted in impaired liver function, decreased IGF-1 secretion, dysregulation of bone metabolism and disruption of the dynamic balance between osteoblasts and osteoclasts in male offspring. F-53B inhibits longitudinal bone growth and development and causes osteoporosis in male offspring. F-53B may affect the growth and development of offspring bone via the IGF-1/OPG/RANKL/CTSK signaling pathway. This study provides new insights for the study of short stature and bone injury caused by F-53B. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0147-6513 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0147651324005773; https://doaj.org/toc/0147-6513 |
| DOI: | 10.1016/j.ecoenv.2024.116501 |
| URL الوصول: | https://doaj.org/article/25eb834e1afe4088817d5af1b080231e |
| رقم الانضمام: | edsdoj.25eb834e1afe4088817d5af1b080231e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 01476513 |
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| DOI: | 10.1016/j.ecoenv.2024.116501 |