Academic Journal
Volume versus surface-based cortical thickness measurements: A comparative study with healthy controls and multiple sclerosis patients.
| العنوان: | Volume versus surface-based cortical thickness measurements: A comparative study with healthy controls and multiple sclerosis patients. |
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| المؤلفون: | R Righart, P Schmidt, R Dahnke, V Biberacher, A Beer, D Buck, B Hemmer, J S Kirschke, C Zimmer, C Gaser, M Mühlau |
| المصدر: | PLoS ONE, Vol 12, Iss 7, p e0179590 (2017) |
| بيانات النشر: | Public Library of Science (PLoS), 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | The cerebral cortex is a highly folded outer layer of grey matter tissue that plays a key role in cognitive functions. In part, alterations of the cortex during development and disease can be captured by measuring the cortical thickness across the whole brain. Available software tools differ with regard to labor intensity and computational demands. In this study, we compared the computational anatomy toolbox (CAT), a recently proposed volume-based tool, with the well-established surface-based tool FreeSurfer. We observed that overall thickness measures were highly inter-correlated, although thickness estimates were systematically lower in CAT than in FreeSurfer. Comparison of multiple sclerosis (MS) patients with age-matched healthy control subjects showed highly comparable clusters of MS-related thinning for both methods. Likewise, both methods yielded comparable clusters of age-related cortical thinning, although correlations between age and average cortical thickness were stronger for FreeSurfer. Our data suggest that, for the analysis of cortical thickness, the volume-based CAT tool can be regarded a considerable alternative to the well-established surface-based FreeSurfer tool. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC5500013?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0179590 |
| URL الوصول: | https://doaj.org/article/d25e94f3b01a4fa9a51c08450942a6fb |
| رقم الانضمام: | edsdoj.25e94f3b01a4fa9a51c08450942a6fb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0179590 |