التفاصيل البيبلوغرافية
| العنوان: |
Clinical and Immunologic Efficacy of the Recombinant Adenovirus Type-5-Vectored (CanSino Bio) Vaccine in University Professors during the COVID-19 Delta Wave |
| المؤلفون: |
Santos Guzmán-López, Armine Darwich-Salazar, Paola Bocanegra-Ibarias, Daniel Salas-Treviño, Samantha Flores-Treviño, Eduardo Pérez-Alba, Laura M. Nuzzolo-Shihadeh, Edelmiro Pérez-Rodríguez, Adrián Camacho-Ortiz |
| المصدر: |
Vaccines, Vol 10, Iss 5, p 656 (2022) |
| بيانات النشر: |
MDPI AG, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Medicine |
| مصطلحات موضوعية: |
COVID 19, vaccine, SARS-CoV-2, immunity, adenovirus vector vaccine, Medicine |
| الوصف: |
Information regarding the efficacy of the recombinant adenovirus type-5-vectored (CanSino Bio) vaccine against the COVID-19 disease in a real-life setting is limited. A retrospective cohort study was carried out in the teaching university community of the metropolitan area of Monterrey, Mexico, through a four-section survey, and during the COVID-19 delta wave. Determination of IgG antibodies against SARS-CoV-2 spike (S) protein was performed in a subset of participants vaccinated with CanSino Bio. A total of 7468 teachers responded to the survey, and 6695 of them were fully vaccinated. Of those, 72.7% had CanSino Bio, 10.3% Pfizer, 8.4% AstraZeneca, 1.2% Moderna, and 2.7% others. Symptomatic breakthrough infections were recorded in those vaccinated with CanSino Bio (4.1%), AstraZeneca (2.1%), and Pfizer (2.2%). No difference was found between CanSino Bio and other vaccines regarding hospitalization, the need for mechanical ventilation, and death. For CanSino Bio recipients, anti-S antibodies were >50 AU/mL in 73.2%. In conclusion, primary breakthrough symptomatic infections were higher in the CanSino vaccinated group compared to other brands. Individuals with a previous infection had higher antibody levels than those who were reinfected and without infection. A boosted dose of CanSino is recommended for those individuals without a previous infection. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2076-393X |
| Relation: |
https://www.mdpi.com/2076-393X/10/5/656; https://doaj.org/toc/2076-393X |
| DOI: |
10.3390/vaccines10050656 |
| URL الوصول: |
https://doaj.org/article/25ddb9f6a9154d04b8f97a610d7f1672 |
| رقم الانضمام: |
edsdoj.25ddb9f6a9154d04b8f97a610d7f1672 |
| قاعدة البيانات: |
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