Academic Journal
Hippo-YAP/TAZ pathway regulation: the crucial roles of lncRNAs in cancer
| العنوان: | Hippo-YAP/TAZ pathway regulation: the crucial roles of lncRNAs in cancer |
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| المؤلفون: | Wonyi Jang, Mijung Im, Jungwook Roh, JiHoon Kang, Wanyeon Kim |
| المصدر: | Animal Cells and Systems, Vol 27, Iss 1, Pp 309-320 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Hippo signaling pathway, long non-coding RNA, TEAD, YAP/TAZ, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | ABSTRACTThe Hippo signaling pathway is a conserved signaling pathway that regulates cell proliferation, apoptosis, and differentiation and plays essential roles in the maintenance of organ size and tissue homeostasis. Also, this signaling pathway is a critical regulator of malignant progression in a wide range of cancers. Furthermore, it has been established that YAP and TAZ are major effectors of the Hippo signaling pathway and transcription co-activators that regulate the expressions of genes involved in cell growth and differentiation. Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides involved in several biological processes, including chromatin remodeling, transcriptional regulation, and post-transcriptional processing. Evidence suggests that the aberrant expression and dysregulation of lncRNAs contribute to the development and progression of various malignancies by acting as oncogenes or tumor suppressors. In addition, many studies have shown that lncRNAs can directly or indirectly regulate the Hippo-YAP/TAZ signaling pathway in cancer. Here, we overview the roles played by lncRNAs in tumor progression with focus on their regulation of the Hippo-YAP/TAZ signaling pathway and discuss their potential usages as clinical biomarkers and therapeutic targets. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 19768354 2151-2485 1976-8354 |
| Relation: | https://doaj.org/toc/1976-8354; https://doaj.org/toc/2151-2485 |
| DOI: | 10.1080/19768354.2023.2281370 |
| URL الوصول: | https://doaj.org/article/25a62bf4e4c64a47846b16b6c6fc1cb2 |
| رقم الانضمام: | edsdoj.25a62bf4e4c64a47846b16b6c6fc1cb2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19768354 21512485 |
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| DOI: | 10.1080/19768354.2023.2281370 |