التفاصيل البيبلوغرافية
| العنوان: |
Antibody Response Induced by BNT162b2 and mRNA-1273 Vaccines against the SARS-CoV-2 in a Cohort of Healthcare Workers |
| المؤلفون: |
Juan F. Delgado, Antoni Berenguer-Llergo, Germà Julià, Gema Navarro, Mateu Espasa, Sara Rodríguez, Noemí Sánchez, Eva Van Den Eynde, Marta Navarro, Joan Calvet, Jordi Gratacós, Rosa M. Serrano, Pilar Peña, María J. Amengual |
| المصدر: |
Viruses, Vol 14, Iss 6, p 1235 (2022) |
| بيانات النشر: |
MDPI AG, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Microbiology |
| مصطلحات موضوعية: |
antibodies, SARS-CoV-2, vaccine, mRNA-1273, BNT162b2, Microbiology, QR1-502 |
| الوصف: |
The aim of this study was to characterize the antibody response induced by SARS-CoV-2 mRNA vaccines in a cohort of healthcare workers. A total of 2247 serum samples were analyzed using the Elecsys® Anti-SARS-CoV-2 S-test (Roche Diagnostics International Ltd., Rotkreuz, Switzerland). Sex, age, body mass index (BMI), arterial hypertension, smoking and time between infection and/or vaccination and serology were considered the confounding factors. Regarding the medians, subjects previously infected with SARS-CoV-2 who preserved their response to the nucleocapsid (N) protein showed higher humoral immunogenicity (BNT162b2: 6456.0 U/mL median; mRNA-1273: 2505.0 U/mL) compared with non-infected (BNT162b2: 867.0 U/mL; mRNA-1273: 2300.5 U/mL) and infected subjects with a lost response to N protein (BNT162b2: 2992.0 U/mL). After controlling for the confounders, a higher response was still observed for mRNA-1273 compared with BNT162b2 in uninfected individuals (FC = 2.35, p < 0.0001) but not in previously infected subjects (1.11 FC, p = 0.1862). The lowest levels of antibodies were detected in previously infected non-vaccinated individuals (39.4 U/mL). Clinical variables previously linked to poor prognoses regarding SARS-CoV-2 infection, such as age, BMI and arterial hypertension, were positively associated with increasing levels of anti-S protein antibody exclusively in infected subjects. The mRNA-1273 vaccine generated a higher antibody response to the S protein than BNT162b2 in non-infected subjects only. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1999-4915 |
| Relation: |
https://www.mdpi.com/1999-4915/14/6/1235; https://doaj.org/toc/1999-4915 |
| DOI: |
10.3390/v14061235 |
| URL الوصول: |
https://doaj.org/article/25560de55937488ca7e8ab90b78550ed |
| رقم الانضمام: |
edsdoj.25560de55937488ca7e8ab90b78550ed |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder