Academic Journal
Implication of FSHB rs10835638 variant in endometriosis in Brazilian women
| العنوان: | Implication of FSHB rs10835638 variant in endometriosis in Brazilian women |
|---|---|
| المؤلفون: | Bianca Bianco, Flávia Altheman Loureiro, Camila Martins Trevisan, Denise Maria Christofolini, Antonio Simone Laganà, Caio Parente Barbosa |
| المصدر: | Einstein (São Paulo), Vol 21 (2023) |
| بيانات النشر: | Instituto Israelita de Ensino e Pesquisa Albert Einstein, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Endometriosis, Follicle stimulating hormone, beta subunit, Infertility, Polymorphism, single nucleotide, Medicine |
| الوصف: | ABSTRACT Objective The follicle-stimulating hormone subunit beta gene rs10835638 variant (c.-211G>T) may have detrimental effects on fertility and protective effects against endometriosis. A case-control analysis was performed, aiming to investigate the possible relationship between this variant and the development and/or progression of endometriosis. Methods This study included 326 women with endometriosis and 482 controls without endometriosis, both confirmed by inspection of the pelvic cavity during surgery. Genotyping was performed using a TaqMan real-time polymerase chain reaction assay. Genotype and allele frequencies and genetic models were compared between the groups. Results The genotype and allele frequencies of the rs10835638 variant did not differ between women with and those without endometriosis. Subdividing the endometriosis group into fertile and infertile groups did not result in a significant difference in these frequencies. However, the subgroup with minimal/mild endometriosis had a higher frequency of the GT genotype than the Control Group, regardless of fertility. The T allele was significantly more common in women with minimal/mild endometriosis than in the Control Group in the recessive model. Conclusion The T allele is associated with the development of minimal/mild endometriosis in Brazilian women. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Portuguese |
| تدمد: | 2317-6385 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082023000100239&tlng=en; https://doaj.org/toc/2317-6385 |
| DOI: | 10.31744/einstein_journal/2023ao0483 |
| URL الوصول: | https://doaj.org/article/24e7054acb484c2e82f9aab15b16cd21 |
| رقم الانضمام: | edsdoj.24e7054acb484c2e82f9aab15b16cd21 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23176385 |
|---|---|
| DOI: | 10.31744/einstein_journal/2023ao0483 |