التفاصيل البيبلوغرافية
| العنوان: |
Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology |
| المؤلفون: |
Keisuke Watanabe, Shunichiro Kuramitsu, Avery D. Posey, Carl H. June |
| المصدر: |
Frontiers in Immunology, Vol 9 (2018) |
| بيانات النشر: |
Frontiers Media S.A., 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
T cell biology, chimeric antigen receptors, immune synapse formation, immunotherapy, cancer immunology, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
A major obstacle for chimeric antigen receptor (CAR) T cell therapy in solid tumors is the lack of truly tumor-specific target antigens, which translates to the targeting of tumor-associated antigens (TAAs) overexpressed on tumors but shared with normal organs, raising safety concerns. In addition, expression of TAAs in solid tumors is particularly heterogeneous. In this regard, it is critical to deeply understand the sensitivity of CAR T cells, especially against low-density targets and the possible therapeutic window of antigen density targeted by CAR T cells. In this review, we discuss the recent findings of mechanisms of antigen recognition through CAR, including immunological synapse formation, and the impact of target antigen density for induction of distinct T cell functions. We also discuss rational strategies to adjust and expand the therapeutic window for effective and safe targeting of solid tumors by CAR T cell platforms. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/article/10.3389/fimmu.2018.02486/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2018.02486 |
| URL الوصول: |
https://doaj.org/article/e240ef07e6e44518b60174328e1690b0 |
| رقم الانضمام: |
edsdoj.240ef07e6e44518b60174328e1690b0 |
| قاعدة البيانات: |
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