التفاصيل البيبلوغرافية
| العنوان: |
Marine Longilenes, Oxasqualenoids with Ser-Thr Protein Phosphatase 2A Inhibition Activity |
| المؤلفون: |
Francisco Cen-Pacheco, Claudia Pérez Manríquez, María Luisa Souto, Manuel Norte, José Javier Fernández, Antonio Hernández Daranas |
| المصدر: |
Marine Drugs, Vol 16, Iss 4, p 131 (2018) |
| بيانات النشر: |
MDPI AG, 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
phosphatase inhibition, marine polyether, longilenes, docking simulation, red alga, Laurencia viridis, Biology (General), QH301-705.5 |
| الوصف: |
The red seaweed Laurencia viridis is a rich source of oxygenated secondary metabolites that were derived from squalene. We report here the structures of three novel compounds, (+)-longilene peroxide (1), longilene (2), and (+)-prelongilene (3) that were isolated from this alga, in addition to other substances, 4 and 5, resulting from their acid-mediated degradation. The effect of compounds 1 and 3 against Ser-Thr protein phosphatase type 2A (PP2A) was evaluated, showing that (+)-longilene peroxide (1) inhibited PP2A (IC50 11.3 μM). In order to explain the interaction between PP2A and compounds 1 and 3, molecular docking simulations onto the PP2A enzyme-binding region were used. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1660-3397 |
| Relation: |
http://www.mdpi.com/1660-3397/16/4/131; https://doaj.org/toc/1660-3397 |
| DOI: |
10.3390/md16040131 |
| URL الوصول: |
https://doaj.org/article/23e3feb7aaba4fb3b30d35d38a01c45a |
| رقم الانضمام: |
edsdoj.23e3feb7aaba4fb3b30d35d38a01c45a |
| قاعدة البيانات: |
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