التفاصيل البيبلوغرافية
| العنوان: |
Molecular characterization of Streptococcus suis isolates recovered from diseased pigs in Europe |
| المؤلفون: |
Kevin Li, Sonia Lacouture, Eric Lewandowski, Eric Thibault, Hubert Gantelet, Marcelo Gottschalk, Nahuel Fittipaldi |
| المصدر: |
Veterinary Research, Vol 55, Iss 1, Pp 1-16 (2024) |
| بيانات النشر: |
BMC, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Veterinary medicine |
| مصطلحات موضوعية: |
Swine infectious diseases, Streptococcus suis, genomic epidemiology, antimicrobial resistance, virulence-associated genes, Europe, Veterinary medicine, SF600-1100 |
| الوصف: |
Abstract Streptococcus suis is a major swine pathogen and zoonotic agent, causing important economic losses to the porcine industry. Here, we used genomics approaches to characterize 251 S. suis isolates recovered from diseased pigs across Belgium, France, Germany, Hungary, the Netherlands, Spain, and the United Kingdom. We identified 13 serotypes, being serotypes 9 and 2 the most prevalent, and 34 sequence types (STs), including 16 novel STs, although ST16 and ST1 dominated the strain population. Phylogenetic analysis revealed complex genetic relationships, notable geographic clustering, and potential differential capacity for capsular switching among serotype 9 isolates. We found antimicrobial resistance (AMR) genes in 85.3% of the isolates, with high frequencies of genes conferring resistance to tetracyclines and macrolides. Specifically, 49.4% of the isolates harbored the tetO gene, and 64.9% possessed the ermB gene. Additionally, we observed a diverse array of virulence-associated genes (VAGs), including the classical VAGs mrp, epf, and sly, with variable presence across different genotypes. The high genetic diversity among European S. suis isolates highlights the importance of targeted antimicrobial use and flexible vaccine strategies. Rapid strain characterization is crucial for optimizing swine health management, enabling tailored interventions like the development of autovaccines to mitigate S. suis infections. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1297-9716 |
| Relation: |
https://doaj.org/toc/1297-9716 |
| DOI: |
10.1186/s13567-024-01366-y |
| URL الوصول: |
https://doaj.org/article/235d87952b8744acbe7efcf5e74a7c70 |
| رقم الانضمام: |
edsdoj.235d87952b8744acbe7efcf5e74a7c70 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder