التفاصيل البيبلوغرافية
| العنوان: |
Teclistamab versus real-world physician’s choice of therapy in triple-class exposed relapsed/refractory multiple myeloma |
| المؤلفون: |
Amrita Krishnan, Ajay K Nooka, Ajai Chari, Alfred L Garfall, Thomas G Martin, Sandhya Nair, Xiwu Lin, Keqin Qi, Anil Londhe, Lixia Pei, Eric Ammann, Rachel Kobos, Jennifer Smit, Trilok Parekh, Alexander Marshall, Mary Slavcev, Saad Z Usmani |
| المصدر: |
Journal of Comparative Effectiveness Research, Vol 12, Iss 6 (2023) |
| بيانات النشر: |
Becaris Publishing Limited, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Public aspects of medicine |
| مصطلحات موضوعية: |
b-cell maturation antigen, bispecific antibody, comparative effectiveness, indirect treatment comparison, majestec-1, Public aspects of medicine, RA1-1270 |
| الوصف: |
Aim: We compared the effectiveness of teclistamab versus real-world physician’s choice of therapy (RWPC) in triple-class exposed relapsed/refractory multiple myeloma. Materials & methods: MajesTEC- 1 eligibility criteria were applied to the RWPC cohort. Baseline covariate imbalances were adjusted using inverse probability of treatment weighting. Overall survival, progression-free survival and time to next treatment were compared. Results: After inverse probability of treatment weighting, baseline characteristics were similar between cohorts (teclistamab, n = 165; RWPC, n = 364 [766 observations]). Teclistamab treated patients had numerically better overall survival (hazard ratio [HR]: 0.82 [95% CI: 0.59– 1.14]; p = 0.233) and significantly greater progression-free survival (HR: 0.43 [0.33–0.56]; p < 0.0001) and time to next treatment (HR: 0.36 [0.27–0.49]; p < 0.0001) versus the RWPC cohort. Conclusion: Teclistamab offered clinical benefit over RWPC in triple-class exposed relapsed/refractory multiple myeloma. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2042-6313 |
| Relation: |
https://doaj.org/toc/2042-6313 |
| DOI: |
10.57264/cer-2022-0186 |
| URL الوصول: |
https://doaj.org/article/d2234f01c82748d787b0b8d1a00b2e7e |
| رقم الانضمام: |
edsdoj.2234f01c82748d787b0b8d1a00b2e7e |
| قاعدة البيانات: |
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