التفاصيل البيبلوغرافية
| العنوان: |
Antitumor and antimetastatic activities of pectic polysaccharides isolated from persimmon leaves mediated by enhanced natural killer cell activity |
| المؤلفون: |
Hye-Ryung Park, Dahyun Hwang, Hee-Do Hong, Kwang-Soon Shin |
| المصدر: |
Journal of Functional Foods, Vol 37, Iss , Pp 460-466 (2017) |
| بيانات النشر: |
Elsevier, 2017. |
| سنة النشر: |
2017 |
| المجموعة: |
LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: |
Persimmon leaf, Antitumor activity, Antimetastatic activity, Macrophage, Natural killer cell, Nutrition. Foods and food supply, TX341-641 |
| الوصف: |
To investigate the antitumor and antimetastatic activities of pectic polysaccharides isolated from persimmon leaves, three polysaccharides (PLE-0, -I, and -II) were prepared. Based on IL-6 cytokine production, PLE-II was selected for further analysis. PLE-II significantly increased IL-6 and IL-12 production in peritoneal macrophages. Moreover, the antitumor and antimetastatic activities of PLE-II were mediated by the activation of natural killer (NK) cells. Depletion of NK cells abolished its antimetastasis activity, thus confirming the role of NK cells in mediating the antimetastatic effect. To determine the commercial potential of PLE, the crude polysaccharide, PLE-0, was administered orally to mice, and its antitumor and antimetastatic activities were evaluated. PLE-0 also induced NK cell-mediated tumoricidal activity and inhibited tumor metastasis in mice in a dose-dependent manner. These data suggest that both PLE-0 and PLE-II have antitumor and antimetastatic activities, and PLE-0 could potentially be used in functional foods and nutraceuticals for cancer prevention. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1756-4646 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1756464617304917; https://doaj.org/toc/1756-4646 |
| DOI: |
10.1016/j.jff.2017.08.027 |
| URL الوصول: |
https://doaj.org/article/2200002a585943c19abb4727f7087cac |
| رقم الانضمام: |
edsdoj.2200002a585943c19abb4727f7087cac |
| قاعدة البيانات: |
Directory of Open Access Journals |