التفاصيل البيبلوغرافية
| العنوان: |
Reduced estrogen signaling contributes to bone loss and cardiac dysfunction in interleukin‐10 knockout mice |
| المؤلفون: |
Sanmi E. Alake, John Ice, Kara Robinson, Payton Price, Bethany Hatter, Karen Wozniak, Dingbo Lin, Winyoo Chowanadisai, Brenda J. Smith, Edralin A. Lucas |
| المصدر: |
Physiological Reports, Vol 12, Iss 1, Pp n/a-n/a (2024) |
| بيانات النشر: |
Wiley, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Physiology |
| مصطلحات موضوعية: |
cardiovascular disease, estrogen, gut inflammation, inflammation, osteoporosis, Physiology, QP1-981 |
| الوصف: |
Abstract Characterization of the interleukin (IL)‐10 knockout (KO) mouse with chronic gut inflammation, cardiovascular dysfunction, and bone loss suggests a critical role for this cytokine in interorgan communication within the gut, bone, and cardiovascular axis. We sought to understand the role of IL‐10 in the cross‐talk between these systems. Six‐week‐old IL‐10 KO mice and their wild type (WT) counterparts were maintained on a standard rodent diet for 3 or 6 months. Gene expression of proinflammatory markers and Fgf23, serum 17β‐estradiol (E2), and cardiac protein expression were assessed. Ileal Il17a and Tnf mRNA increased while Il6 mRNA increased in the bone and heart by at least 2‐fold in IL‐10 KO mice. Bone Dmp1 and Phex mRNA were repressed at 6 months in IL‐10 KO mice, resulting in increased Fgf23 mRNA (~4‐fold) that contributed to increased fibrosis. In the IL‐10 KO mice, gut bacterial β‐glucuronidase activity and ovarian Cyp19a1 mRNA were lower (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2051-817X |
| Relation: |
https://doaj.org/toc/2051-817X |
| DOI: |
10.14814/phy2.15914 |
| URL الوصول: |
https://doaj.org/article/219ff34f13294f2884baea9761adc062 |
| رقم الانضمام: |
edsdoj.219ff34f13294f2884baea9761adc062 |
| قاعدة البيانات: |
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