التفاصيل البيبلوغرافية
| العنوان: |
Optokinetic set-point adaptation functions as an internal dynamic calibration mechanism for oculomotor disequilibrium |
| المؤلفون: |
Ting-Feng Lin, Mohammad Mohammadi, Kathleen E. Cullen, Maurice J. Chacron, Melody Ying-Yu Huang |
| المصدر: |
iScience, Vol 25, Iss 11, Pp 105335- (2022) |
| بيانات النشر: |
Elsevier, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Biological sciences, neuroscience, sensory neuroscience, Science |
| الوصف: |
Summary: Experience-dependent brain circuit plasticity underlies various sensorimotor learning and memory processes. Recently, a novel set-point adaptation mechanism was identified that accounts for the pronounced negative optokinetic afternystagmus (OKAN) following a sustained period of unidirectional optokinetic nystagmus (OKN) in larval zebrafish. To investigate the physiological significance of optokinetic set-point adaptation, animals in the current study were exposed to a direction-alternating optokinetic stimulation paradigm that better resembles their visual experience in nature. Our results reveal that not only was asymmetric alternating stimulation sufficient to induce the set-point adaptation and the resulting negative OKAN, but most strikingly, under symmetric alternating stimulation some animals displayed an inherent bias of the OKN gain in one direction, and that was compensated by the similar set-point adaptation. This finding, supported by mathematical modeling, suggests that set-point adaptation allows animals to cope with asymmetric optokinetic behaviors evoked by either external stimuli or innate oculomotor biases. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004222016078; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2022.105335 |
| URL الوصول: |
https://doaj.org/article/c21508523bb3427d9eb27444acbef109 |
| رقم الانضمام: |
edsdoj.21508523bb3427d9eb27444acbef109 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder