التفاصيل البيبلوغرافية
| العنوان: |
The efficacy of curcumin/Qing Dai combination in children with active ulcerative colitis: a multicenter retrospective cohort study |
| المؤلفون: |
Nurit Loberman Nachum, Nir Salomon, Anat Yerushalmy-Feler, Yael Weintraub, Dotan Yogev, Maya Granot, Yael Haberman, Shomron Ben-Horin, Batia Weiss |
| المصدر: |
Frontiers in Pediatrics, Vol 12 (2024) |
| بيانات النشر: |
Frontiers Media S.A., 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Pediatrics |
| مصطلحات موضوعية: |
Qing Dai, curcumin, ulcerative colitis, pediatric, management, Pediatrics, RJ1-570 |
| الوصف: |
BackgroundCurcumin and Qing Dai (QD) are herbal extracts that recently showed efficacy in treating inflammatory bowel disease (IBD). Since 2016, a combination of curcumin with QD (CurQD) has been employed in our center for management of active ulcerative colitis (UC).ObjectivesWe report the effectiveness and safety of CurQD therapy in children with mild-moderate UC or IBD-unclassified (IBD-U).DesignA multicenter retrospective study.MethodsChildren aged ≤OP18 years who were treated with CurQD during 2017–2021 were included. Disease activity measures were Pediatric UC Activity Index (PUCAI), and fecal calprotectin (FC). The primary outcome was a decrease in PUCAI by ≥10 points, FC normalization (≤100 µg/gr when baseline ≥300 µg/gr) or a ≥ 50% decrease in FC.ResultsOf 30 patients (60% males, mean age 14 ± 3.9 years), 15 (50%), 13 (43%), and 2 (7%) had pancolitis, left-sided colitis and proctitis, respectively. The daily medication dose was 0.5–3 gm QD with 1–4 gm curcumin. Concomitant treatment at induction was corticosteroids (19%), biologics (28%) and 5-aminosalicylic acid (40%). The mean duration of induction was 11.6 weeks [95% confidence interval (CI) 10.2–13.1, range 8–16]. PUCAI decreased from a mean of 31.3 (95% CI 26.6–36.0, range 5–60) to 10.9 (95% CI 7.6–14.4, range 5–35) (n = 26, p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-2360 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fped.2024.1342656/full; https://doaj.org/toc/2296-2360 |
| DOI: |
10.3389/fped.2024.1342656 |
| URL الوصول: |
https://doaj.org/article/213bd003db4f47878ad1888e5e3b5483 |
| رقم الانضمام: |
edsdoj.213bd003db4f47878ad1888e5e3b5483 |
| قاعدة البيانات: |
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