Academic Journal
Evaluation of Vitamin C Supplementation on Kidney Function and Vascular Reactivity Following Renal Ischemic Injury in Mice
| العنوان: | Evaluation of Vitamin C Supplementation on Kidney Function and Vascular Reactivity Following Renal Ischemic Injury in Mice |
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| المؤلفون: | Yao-Bin Zhu, Ya-Ping Zhang, Jing Zhang, Yan-Bo Zhang |
| المصدر: | Kidney & Blood Pressure Research, Vol 41, Iss 4, Pp 460-470 (2016) |
| بيانات النشر: | Karger Publishers, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Dermatology LCC:Diseases of the circulatory (Cardiovascular) system LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | Ischemia/reperfusion injury, Vascular reactivity, Vitamin C, Oxidative stress, Dermatology, RL1-803, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | Background/Aims: Renal ischemia/reperfusion injury (IRI) is a very common clinical event and usually leads to ischemic acute renal failure (ARF). In the present study, we investigated the protective role of vitamin C in renal function and renal arterial relaxation following ischemic injury. Methods: IRI model in mice was used. Various biochemical parameters including nitric oxide (NO), reduced glutathione (GSH), total reactive oxygen species (ROS) level and superoxide dismutase (SOD) were examined. Doppler was used to investigate renal arterial resistance. The isolated renal arterial rings served for hypoxia/reoxygenation analysis. Acetylcholine (ACh) and sodium nitroprusside (SNP)-induced relaxations of isolated renal arterial rings were exerted. Results: Vitamin C supplementation preserved kidney morphology and renal function following IRI. It was shown that pretreatment with vitamin C for mice subjected to IRI significantly elevated renal NO and GSH levels after reperfusion. Meanwhile, vitamin C administration decreased resistance index of renal artery and ameliorated oxidative stress secondary to IRI. The total ROS level in renal artery was decreased whereas the renal arterial SOD expression was increased by vitamin C supplementation following IRI. Pretreatment with vitamin C significantly potentiated the ACh and SNP-induced relaxations in both control and hypoxic renal arterial rings. Conclusion: Vitamin C protects kidney function and renal arterial reactivity against IRI. The protective role of vitamin C is linked to ROS, SOD, GSH and NO levels in renal ischemic injury. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1420-4096 1423-0143 |
| Relation: | http://www.karger.com/Article/FullText/443447; https://doaj.org/toc/1420-4096; https://doaj.org/toc/1423-0143 |
| DOI: | 10.1159/000443447 |
| URL الوصول: | https://doaj.org/article/21275deed4964afca8818f7d306540a5 |
| رقم الانضمام: | edsdoj.21275deed4964afca8818f7d306540a5 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 14204096 14230143 |
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| DOI: | 10.1159/000443447 |