التفاصيل البيبلوغرافية
| العنوان: |
miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation |
| المؤلفون: |
Young Ho Ban, Se-Chan Oh, Sang-Hwan Seo, Seok-Min Kim, In-Pyo Choi, Philip D. Greenberg, Jun Chang, Tae-Don Kim, Sang-Jun Ha |
| المصدر: |
Cell Reports, Vol 20, Iss 11, Pp 2598-2611 (2017) |
| بيانات النشر: |
Elsevier, 2017. |
| سنة النشر: |
2017 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
miR-150, Foxo1, CD8, memory, differentiation, acute, infection, primary immune response, recall, LCMV, Biology (General), QH301-705.5 |
| الوصف: |
MicroRNA (miR)-150 is a developmental regulator of several immune-cell types, but its role in CD8+ T cells is largely unexplored. Here, we show that miR-150 regulates the generation of memory CD8+ T cells. After acute virus infection, miR-150 knockout (KO) mice exhibited an accelerated differentiation of CD8+ T cells into memory cells and improved production of effector cytokines. Additionally, miR-150 KO CD8+ T cells displayed an enhanced recall response and improved protection against infections with another virus and bacteria. We found that forkhead box O1 (Foxo1) and T cell-specific transcription factor 1 (TCF1) are upregulated during the early activation phase in miR-150 KO CD8+ T cells and that miR-150 directly targets and suppresses Foxo1. These results suggest that miR-150-mediated suppression of Foxo1 regulates the balance between effector and memory cell differentiation, which might aid in the development of improved vaccines and T cell therapeutics. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2211-1247 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2211124717311907; https://doaj.org/toc/2211-1247 |
| DOI: |
10.1016/j.celrep.2017.08.065 |
| URL الوصول: |
https://doaj.org/article/d20d629665504a819430e9c6157aee50 |
| رقم الانضمام: |
edsdoj.20d629665504a819430e9c6157aee50 |
| قاعدة البيانات: |
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