التفاصيل البيبلوغرافية
| العنوان: |
An interpretable deep learning framework for predicting liver metastases in postoperative colorectal cancer patients using natural language processing and clinical data integration |
| المؤلفون: |
Jia Li, Xinghao Wang, Linkun Cai, Jing Sun, Zhenghan Yang, Wenjuan Liu, Zhenchang Wang, Han Lv |
| المصدر: |
Cancer Medicine, Vol 12, Iss 18, Pp 19337-19351 (2023) |
| بيانات النشر: |
Wiley, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
artificial intelligence, bidirectional encoding representation of transformer, electronic health records, interpretable deep learning, natural language processing, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Abstract Background The significance of liver metastasis (LM) in increasing the risk of death for postoperative colorectal cancer (CRC) patients necessitates innovative approaches to predict LM. Aim Our study presents a novel and significant contribution by developing an interpretable fusion model that effectively integrates both free‐text medical record data and structured laboratory data to predict LM in postoperative CRC patients. Methods We used a robust dataset of 1463 patients and leveraged state‐of‐the‐art natural language processing (NLP) and machine learning techniques to construct a two‐layer fusion framework that demonstrates superior predictive performance compared to single modal models. Our innovative two‐tier algorithm fuses the results from different data modalities, achieving balanced prediction results on test data and significantly enhancing the predictive ability of the model. To increase interpretability, we employed Shapley additive explanations to elucidate the contributions of free‐text clinical data and structured clinical data to the final model. Furthermore, we translated our findings into practical clinical applications by creating a novel NLP score‐based nomogram using the top 13 valid predictors identified in our study. Results The proposed fusion models demonstrated superior predictive performance with an accuracy of 80.8%, precision of 80.3%, recall of 80.5%, and an F1 score of 80.8% in predicting LMs. Conclusion This fusion model represents a notable advancement in predicting LMs for postoperative CRC patients, offering the potential to enhance patient outcomes and support clinical decision‐making. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2045-7634 |
| Relation: |
https://doaj.org/toc/2045-7634 |
| DOI: |
10.1002/cam4.6523 |
| URL الوصول: |
https://doaj.org/article/20804503d3dc47199741bcac05222001 |
| رقم الانضمام: |
edsdoj.20804503d3dc47199741bcac05222001 |
| قاعدة البيانات: |
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