Academic Journal
Recent advances, challenges and updates on the development of therapeutics for malaria
| العنوان: | Recent advances, challenges and updates on the development of therapeutics for malaria |
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| المؤلفون: | Rimmy Nandal, Davinder Kumar, Navidha Aggarwal, Virender Kumar, Balasubramanian Narasimhan, Rakesh Kumar Marwaha, Prabodh Chander Sharma, Surender Kumar, Nitin Bansal, Hitesh Chopra, Aakash Deep |
| المصدر: | EXCLI Journal : Experimental and Clinical Sciences, Vol 23, Pp 672-713 (2024) |
| بيانات النشر: | IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Biology (General) |
| مصطلحات موضوعية: | antimalarials, clinical trials, malaria, tafenoquine, cipargamin, artefenomel, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Biology (General), QH301-705.5 |
| الوصف: | Malaria has developed as a serious worldwide health issue as a result of the introduction of resistant Plasmodium species strains. Because of the common chemo resistance to most of the existing drugs on the market, it poses a severe health problem and significant obstacles in drug research. Malaria treatment has evolved during the last two decades in response to Plasmodium falciparum drug sensitivity and a return of the disease in tropical areas. Plasmodium falciparum is now highly resistant to the majority of antimalarial drugs. The parasite resistance drew focus to developing novel antimalarials to combat parasite resistance. The requirement for many novel antimalarial drugs in the future year necessitates adopting various drug development methodologies. Different innovative strategies for discovering antimalarial drugs are now being examined here. This review is primarily concerned with the description of newly synthesized antimalarial compounds, i.e. Tafenoquine, Cipargamin, Ferroquine, Artefenomel, DSM265, MMV390048 designed to improve the activity of pure antimalarial enantiomers. In this review, we selected the representative malarial drugs in clinical trials, classified them with detailed targets according to their action, discussed the relationship within the human trials, and generated a summative discussion with prospective expectations. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1611-2156 |
| Relation: | https://www.excli.de/excli/article/view/6856; https://doaj.org/toc/1611-2156 |
| DOI: | 10.17179/excli2023-6856 |
| URL الوصول: | https://doaj.org/article/202fcb5419494dc49082aaec1efb65a6 |
| رقم الانضمام: | edsdoj.202fcb5419494dc49082aaec1efb65a6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16112156 |
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| DOI: | 10.17179/excli2023-6856 |