Academic Journal
Neem oil nanoemulsions: characterisation and antioxidant activity
| العنوان: | Neem oil nanoemulsions: characterisation and antioxidant activity |
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| المؤلفون: | Federica Rinaldi, Patrizia Nadia Hanieh, Catia Longhi, Simone Carradori, Daniela Secci, Gokhan Zengin, Maria Grazia Ammendolia, Elena Mattia, Elena Del Favero, Carlotta Marianecci, Maria Carafa |
| المصدر: | Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 1265-1273 (2017) |
| بيانات النشر: | Taylor & Francis Group, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Neem oil, nanoemulsions, physicochemical characterisation, antioxidant activity, cell interaction studies, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | The aim of the present work is to develop nanoemulsions (NEs), nanosized emulsions, manufactured for improving the delivery of active pharmaceutical ingredients. In particular, nanoemulsions composed of Neem seed oil, contain rich bioactive components, and Tween 20 as nonionic surfactant were prepared. A mean droplet size ranging from 10 to 100 nm was obtained by modulating the oil/surfactant ratio. Physicochemical characterisation was carried out evaluating size, ζ-potential, microviscosity, polarity and turbidity of the external shell and morphology, along with stability in simulated cerebrospinal fluid (CSF), activity of Neem oil alone and in NEs, HEp-2 cell interaction and cytotoxicity studies. This study confirms the formation of NEs by Tween 20 and Neem oil at different weight ratios with small and homogenous dimensions. The antioxidant activity of Neem oil alone and in NEs was comparable, whereas its cytotoxicity was strongly reduced when loaded in NEs after interaction with HEp-2 cells. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1475-6366 1475-6374 14756366 |
| Relation: | https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374 |
| DOI: | 10.1080/14756366.2017.1378190 |
| URL الوصول: | https://doaj.org/article/20272c3d967e4adaa55df2cf2cb694d8 |
| رقم الانضمام: | edsdoj.20272c3d967e4adaa55df2cf2cb694d8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14756366 14756374 |
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| DOI: | 10.1080/14756366.2017.1378190 |