Academic Journal
أعرض في EDS

Association study of matrix metalloproteinase 3 5A/6A polymorphism with in-stent restenosis after percutaneous coronary interventions in a Han Chinese population

التفاصيل البيبلوغرافية
العنوان: Association study of matrix metalloproteinase 3 5A/6A polymorphism with in-stent restenosis after percutaneous coronary interventions in a Han Chinese population
المؤلفون: Ji-Bing Du, Wei Zhang, Na Li, Hua Jiang, Yin Liu, Jing Gao, Shu-Tao Chen, Hong-Liang Cong, Yi-Liang Wei
المصدر: Journal of International Medical Research, Vol 48 (2020)
بيانات النشر: SAGE Publishing, 2020.
سنة النشر: 2020
المجموعة: LCC:Medicine (General)
مصطلحات موضوعية: Medicine (General), R5-920
الوصف: Objective We aimed to investigate the association between the 5A/6A promoter polymorphism in the matrix metalloproteinase 3 ( MMP3 ) gene and in-stent restenosis (ISR) in a regional Chinese population. Methods A total of 818 patients who underwent primary implantation of drug-eluting stents were enrolled and received a 6-month follow-up angiography and DNA genotyping of the 5A/6A polymorphism. Results ISR was found in 36.9% of all patients (302 ISR vs. 516 no ISR). The genotype proportion of 6A6A was significantly increased in ISRs (74.2% ISR vs. 66.8% no ISR), whereas the allele frequency of 5A was significantly decreased in ISR patients (25.8%) compared with controls who did not undergo ISR (33.1%). Conclusions Our data indicate that the MMP3 6A6A genotype is a genetic susceptibility factor for ISR after coronary stent placement, but the 5A allele can lower the risk for patients within 6 months after stenting. Therefore, genotyping 5A/6A in the MMP3 promoter is suggested for patients who undergo coronary stent implantation.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1473-2300
03000605
09751998
Relation: https://doaj.org/toc/1473-2300
DOI: 10.1177/0300060519827145
URL الوصول: https://doaj.org/article/1ffea4d7335b43688e09751998745afb
رقم الانضمام: edsdoj.1ffea4d7335b43688e09751998745afb
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14732300
03000605
09751998
DOI:10.1177/0300060519827145