Academic Journal
Association between plasma levels of BDNF and the antisuicidal effects of repeated ketamine infusions in depression with suicidal ideation
| العنوان: | Association between plasma levels of BDNF and the antisuicidal effects of repeated ketamine infusions in depression with suicidal ideation |
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| المؤلفون: | Wei Zheng, Yan-Ling Zhou, Cheng-Yu Wang, Xiao-Feng Lan, Bin Zhang, Su-Miao Zhou, Su Yan, Ming-Zhe Yang, Sha Nie, Yu-Ping Ning |
| المصدر: | Therapeutic Advances in Psychopharmacology, Vol 10 (2020) |
| بيانات النشر: | SAGE Publishing, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Therapeutics. Pharmacology LCC:Psychiatry |
| مصطلحات موضوعية: | Therapeutics. Pharmacology, RM1-950, Psychiatry, RC435-571 |
| الوصف: | Background: This study is the first to examine the association between plasma levels of brain-derived neurotrophic factor (BDNF) and the antisuicidal effects of repeated ketamine infusions in depressed patients with suicidal ideation. Methods: Fifty-seven depressed patients with suicidal ideation received six ketamine infusions (0.5 mg/kg) during a 12 days period. Suicidality was measured with the Scale for Suicidal Ideations (SSI-part 1), item 10 of the Montgomery–Åsberg Depression Rating Scale (MADRS), and item 3 of the Hamilton Depression Rating Scale (HAMD) at baseline, 1 day after the first infusion (1 day), 1 day after the sixth infusion (13 days), and at 2 weeks after the last infusion (26 days). Plasma levels of BDNF were measured by enzyme-linked immunosorbent assay at baseline, 13 days, and 26 days. Results: Overall, 46 (80.7%) depressed patients with suicidal ideation had an antisuicidal response at 13 days. Despite a significant reduction in suicidal symptoms over time, no changes in plasma levels of BDNF were found after ketamine treatment when compared with baseline. Correlation analysis showed that no significant association was observed between the plasma levels of BDNF and the changes in the severity of suicidal symptoms as measured by SSI-part 1, item 10 of the MADRS, or item 3 of the HAMD at 1 day, 13 days, and 26 days (all p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-1261 20451253 |
| Relation: | https://doaj.org/toc/2045-1261 |
| DOI: | 10.1177/2045125320973794 |
| URL الوصول: | https://doaj.org/article/1fd9bc964d304f6a862272ba0da2d021 |
| رقم الانضمام: | edsdoj.1fd9bc964d304f6a862272ba0da2d021 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20451261 20451253 |
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| DOI: | 10.1177/2045125320973794 |