التفاصيل البيبلوغرافية
| العنوان: |
The mutational impact of culturing human pluripotent and adult stem cells |
| المؤلفون: |
Ewart Kuijk, Myrthe Jager, Bastiaan van der Roest, Mauro D. Locati, Arne Van Hoeck, Jerome Korzelius, Roel Janssen, Nicolle Besselink, Sander Boymans, Ruben van Boxtel, Edwin Cuppen |
| المصدر: |
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| بيانات النشر: |
Nature Portfolio, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
Genetic changes acquired during in vitro culture pose a challenge to application of stem cells. Here the authors use whole genome sequencing to show that cultured human adult and pluripotent stem cells have a high mutational load caused by oxidative stress and reduced oxygen tension in culture lowers mutation rates. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-020-16323-4 |
| URL الوصول: |
https://doaj.org/article/1f6a475491464666a79c0e3f7512c41e |
| رقم الانضمام: |
edsdoj.1f6a475491464666a79c0e3f7512c41e |
| قاعدة البيانات: |
Directory of Open Access Journals |
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