Academic Journal
Syphilitic infection impairs immunity by inducing both apoptosis and pyroptosis of CD4 and CD8 T lymphocytes
| العنوان: | Syphilitic infection impairs immunity by inducing both apoptosis and pyroptosis of CD4 and CD8 T lymphocytes |
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| المؤلفون: | Wei Xia, Jinxue Zhao, Bin Su, Yanmei Jiao, Wenjia Weng, Ming Zhang, Xiaodan Wang, Caiping Guo, Hao Wu, Tong Zhang, Yanqing Gao, Zaicun Li |
| المصدر: | Innate Immunity, Vol 27 (2021) |
| بيانات النشر: | SAGE Publishing, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: | Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Syphilis is an important health problem worldwide; however, few studies have probed the impact of syphilitic infection on T cell turnover. The mechanisms behind the frequency of T cell subset changes and the associations between these subsets during syphilitic infection remain unclear. Herein, we used a cell-staining method and flow cytometry to explore changes in T cell subpopulations and potential contribution of apoptosis and pyroptosis that triggered therein. We investigated caspase-1-mediated pyroptosis and caspase-3-mediated apoptosis of CD4 + and CD8 + T cells, the major effector lymphocytes with pivotal roles in the pathogenesis of infectious diseases. We found that the levels of caspase-1 and caspase-3 increased in both the circulation and intracellularly in CD4 + and CD8 + T cells. Caspase-1 showed a continual increase from early latent stage infection through to phase 2 disease, whereas caspase-3 increased through to phase 1 disease but declined during phase 2. In addition, serum levels and intracellular expression of caspase-1 and caspase-3 were positively correlated. Overall, this study increases our understanding of how syphilitic infection influences CD4 + and CD8 + T-cell turnover, which may help with designing novel and effective strategies to control syphilis infection and prevent its transmission. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1753-4259 1753-4267 17534259 |
| Relation: | https://doaj.org/toc/1753-4259; https://doaj.org/toc/1753-4267 |
| DOI: | 10.1177/1753425920952840 |
| URL الوصول: | https://doaj.org/article/1f67ca1a4be247a68d4a7885c2840ec0 |
| رقم الانضمام: | edsdoj.1f67ca1a4be247a68d4a7885c2840ec0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17534259 17534267 |
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| DOI: | 10.1177/1753425920952840 |