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Reduction in the Nephrotoxicity of Amphotericin B when Administered in 20% Intralipid

التفاصيل البيبلوغرافية
العنوان: Reduction in the Nephrotoxicity of Amphotericin B when Administered in 20% Intralipid
المؤلفون: Suzette Salama, Coleman Rotstein
المصدر: Canadian Journal of Infectious Diseases, Vol 8, Iss 3, Pp 157-160 (1997)
بيانات النشر: Hindawi Limited, 1997.
سنة النشر: 1997
المجموعة: LCC:Infectious and parasitic diseases
مصطلحات موضوعية: Infectious and parasitic diseases, RC109-216
الوصف: The administration of amphotericin B (AmB) is often limited by the development of nephrotoxicity. In a pilot crossover trial, aqueous AmB followed by a new preparation of a mixture of AmB with 20% intralipid (AmB-IL) was administered to 10 immunocompromised patients for systemic fungal infections caused by Candida species. Mean total dose and duration of therapy with AmB-IL exceeded that of aqueous AmB (649±165 mg versus 394±105 mg, P=0.061 and 13.2±2.5 days versus 9±2.1 days, P=0.31). However, mean creatinine clearance of the patients rose during AmB-IL therapy by 10.7±7.7 mL/min (P=0.03). AmB-IL warrants further investigation to assess its stability and efficacy for treating serious fungal infections.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1180-2332
Relation: https://doaj.org/toc/1180-2332
DOI: 10.1155/1997/827297
URL الوصول: https://doaj.org/article/1f463bf7c26c4187a36b210e717dd9c3
رقم الانضمام: edsdoj.1f463bf7c26c4187a36b210e717dd9c3
قاعدة البيانات: Directory of Open Access Journals
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