التفاصيل البيبلوغرافية
| العنوان: |
Reduction in the Nephrotoxicity of Amphotericin B when Administered in 20% Intralipid |
| المؤلفون: |
Suzette Salama, Coleman Rotstein |
| المصدر: |
Canadian Journal of Infectious Diseases, Vol 8, Iss 3, Pp 157-160 (1997) |
| بيانات النشر: |
Hindawi Limited, 1997. |
| سنة النشر: |
1997 |
| المجموعة: |
LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: |
Infectious and parasitic diseases, RC109-216 |
| الوصف: |
The administration of amphotericin B (AmB) is often limited by the development of nephrotoxicity. In a pilot crossover trial, aqueous AmB followed by a new preparation of a mixture of AmB with 20% intralipid (AmB-IL) was administered to 10 immunocompromised patients for systemic fungal infections caused by Candida species. Mean total dose and duration of therapy with AmB-IL exceeded that of aqueous AmB (649±165 mg versus 394±105 mg, P=0.061 and 13.2±2.5 days versus 9±2.1 days, P=0.31). However, mean creatinine clearance of the patients rose during AmB-IL therapy by 10.7±7.7 mL/min (P=0.03). AmB-IL warrants further investigation to assess its stability and efficacy for treating serious fungal infections. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1180-2332 |
| Relation: |
https://doaj.org/toc/1180-2332 |
| DOI: |
10.1155/1997/827297 |
| URL الوصول: |
https://doaj.org/article/1f463bf7c26c4187a36b210e717dd9c3 |
| رقم الانضمام: |
edsdoj.1f463bf7c26c4187a36b210e717dd9c3 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder