Academic Journal
Bevacizumab-Induced Thrombotic Microangiopathy (TMA) in Metastatic Lung Adenocarcinoma Patients Receiving Nivolumab Combined with Bevacizumab, Carboplatin and Paclitaxel: Two Case Reports
| العنوان: | Bevacizumab-Induced Thrombotic Microangiopathy (TMA) in Metastatic Lung Adenocarcinoma Patients Receiving Nivolumab Combined with Bevacizumab, Carboplatin and Paclitaxel: Two Case Reports |
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| المؤلفون: | Ping-Chih Hsu, Tai-Di Chen, Tsung-Yu Tsai, Cheng-Ta Yang |
| المصدر: | Clinics and Practice, Vol 13, Iss 1, Pp 200-205 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | bevacizumab, proteinuria, thrombotic microangiopathy (TMA), immunotherapy, nivolumab, ant-PD-1, Medicine (General), R5-920 |
| الوصف: | Anti-programmed death-1 (PD-1)/programmed death ligand 1 (PD-L1) immune checkpoint inhibitors (ICIs), combined with bevacizumab and platinum-based chemotherapy, have shown promising efficacy in treating metastatic non-squamous cell lung cancer in phase 3 clinical trials. However, drug-induced nephrotoxicity is an uncommon but threatening adverse effect when using this combination therapy, and should be evaluated and managed carefully. Here, we present two patients experiencing late-onset asymptomatic heavy proteinuria during the clinical trial. Kidney biopsies performed finally identified bevacizumab-induced thrombotic microangiopathy (TMA), and the proteinuria was decreased after discontinuing bevacizumab permanently. Our report suggests that a kidney biopsy is needed for those receiving ICIs in combination with bevacizumab and chemotherapy and experiencing nephrotoxicity such as heavy proteinuria. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13010018 2039-7283 |
| Relation: | https://www.mdpi.com/2039-7283/13/1/18; https://doaj.org/toc/2039-7283 |
| DOI: | 10.3390/clinpract13010018 |
| URL الوصول: | https://doaj.org/article/1f3d8fff626b45e78d0c0618cdbb3e84 |
| رقم الانضمام: | edsdoj.1f3d8fff626b45e78d0c0618cdbb3e84 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13010018 20397283 |
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| DOI: | 10.3390/clinpract13010018 |