Academic Journal
An unmet need: Pancreatic beta cell replacement
| العنوان: | An unmet need: Pancreatic beta cell replacement |
|---|---|
| المؤلفون: | F Mohamed, C Adams, B Mansfield |
| المصدر: | South African Medical Journal, Vol 114, Iss 3b (2024) |
| بيانات النشر: | South African Medical Association, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | Diabetes, Pancreatic transplant, Islet transplant, Medicine, Medicine (General), R5-920 |
| الوصف: | Diabetes mellitus (DM) is a growing public health concern in South Africa (SA) and poses a substantial economic burden on healthcare globally. A century has passed since the discovery of insulin, and despite advances in diabetes management, exogenous insulin remains a primary treatment for type 1 DM, posing challenges of hyperglycaemia and hypoglycaemia. Pancreas transplantation should be considered a treatment for insulin-deficient DM, offering sustained euglycaemia and preventing complications associated with the disease. However, there has been a global decrease in the number of transplants performed. In SA, only a few pancreas transplants have been performed, primarily because of surgical risks and the need for immunosuppression. Islet transplantation is an alternative but faces limitations due to donor scarcity and immunosuppression requirements. This review explores recent progress in pancreas and islet transplants for DM, with the aim of providing insights into expanding treatment options for people with insulin-deficient DM. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0256-9574 2078-5135 |
| Relation: | https://samajournals.co.za/index.php/samj/article/view/1249; https://doaj.org/toc/0256-9574; https://doaj.org/toc/2078-5135 |
| DOI: | 10.7196/SAMJ.2024.v114i3b.1249 |
| URL الوصول: | https://doaj.org/article/1e5ad656eff24700ab892c9e1f12e5d5 |
| رقم الانضمام: | edsdoj.1e5ad656eff24700ab892c9e1f12e5d5 |
| قاعدة البيانات: | Directory of Open Access Journals |
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