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An unmet need: Pancreatic beta cell replacement

التفاصيل البيبلوغرافية
العنوان: An unmet need: Pancreatic beta cell replacement
المؤلفون: F Mohamed, C Adams, B Mansfield
المصدر: South African Medical Journal, Vol 114, Iss 3b (2024)
بيانات النشر: South African Medical Association, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Medicine (General)
مصطلحات موضوعية: Diabetes, Pancreatic transplant, Islet transplant, Medicine, Medicine (General), R5-920
الوصف: Diabetes mellitus (DM) is a growing public health concern in South Africa (SA) and poses a substantial economic burden on healthcare globally. A century has passed since the discovery of insulin, and despite advances in diabetes management, exogenous insulin remains a primary treatment for type 1 DM, posing challenges of hyperglycaemia and hypoglycaemia. Pancreas transplantation should be considered a treatment for insulin-deficient DM, offering sustained euglycaemia and preventing complications associated with the disease. However, there has been a global decrease in the number of transplants performed. In SA, only a few pancreas transplants have been performed, primarily because of surgical risks and the need for immunosuppression. Islet transplantation is an alternative but faces limitations due to donor scarcity and immunosuppression requirements. This review explores recent progress in pancreas and islet transplants for DM, with the aim of providing insights into expanding treatment options for people with insulin-deficient DM.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0256-9574
2078-5135
Relation: https://samajournals.co.za/index.php/samj/article/view/1249; https://doaj.org/toc/0256-9574; https://doaj.org/toc/2078-5135
DOI: 10.7196/SAMJ.2024.v114i3b.1249
URL الوصول: https://doaj.org/article/1e5ad656eff24700ab892c9e1f12e5d5
رقم الانضمام: edsdoj.1e5ad656eff24700ab892c9e1f12e5d5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:02569574
20785135
DOI:10.7196/SAMJ.2024.v114i3b.1249