التفاصيل البيبلوغرافية
| العنوان: |
Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives |
| المؤلفون: |
Qing-Hao Jin, Zhi-Yang Fu, Ya-Nan Xia, Bing-Yu Liu, Hai-Ying Jiang |
| المصدر: |
Brazilian Journal of Pharmaceutical Sciences, Vol 56 (2020) |
| بيانات النشر: |
Universidade de São Paulo, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: |
Flavonoids, Synthesis, Isoprenyloxyflavones, Antibacterial activity, Pharmacy and materia medica, RS1-441 |
| الوصف: |
In the present study, a series of novel 5,7-diisoprenyloxyflavone derivatives were designed, synthesized, and evaluated for their antibacterial activity. Most of these compounds displayed significant antibacterial effects against Gram-positive bacteria, especially against strains of multidrug-resistant clinical isolates. Compounds 4c, 4g, 4i, 4j, 4k, 4l, 4n, 4q and 4t showed high levels of antimicrobial activity against Staphylococcus aureus RN4220 with minimum inhibitory concentrations of 4.0-20 µM. Compound 4k showed the most potent activity among these compounds against all multidrug-resistant clinical isolates tested. Unfortunately, none of the compounds were active against Gram-negative bacteria at the doses of 24-164 µM. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2175-9790 |
| Relation: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100541&tlng=en; https://doaj.org/toc/2175-9790 |
| DOI: |
10.1590/s2175-97901919000417721 |
| URL الوصول: |
https://doaj.org/article/1e3a40f1d84245c69a4da302c40502a6 |
| رقم الانضمام: |
edsdoj.1e3a40f1d84245c69a4da302c40502a6 |
| قاعدة البيانات: |
Directory of Open Access Journals |